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Pharmacological testing in the spared nerve injury model of neuropathic pain /Rode, Frederik. January 2005 (has links)
Ph.D.
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The contribution of metabotropic glutamate receptors to models of persistent and chronic pain /Fisher, Kim Nüel. January 1998 (has links)
The possible involvement of spinal metabotropic glutamate receptors (mGluRs) were examined in animal models of persistent and chronic pain. In Study 1, it was shown that spinal administration of relatively selective group I mGluR antagonists, or a selective group III mGluR agonist, but not a non-selective mGluR antagonist, slightly, but significantly reduced nociceptive scores in the rat formalin test Also, spinal administration of a non-selective mGluR agonist, or a selective group I mGluR agonist, but not a relatively selective group II agonist, enhanced formalin-induced nociception. The pro-nociceptive effects of these agents were reversed by a non-selective mGluR antagonist or by an N-methyl-D-aspartate receptor (NMDAR) antagonist. In Study 2, it was shown that intrathecal administration of two non-selective mGluR agonists or a selective group I mGluR agonist, but not a selective group II or group III mGluR agonist, produced spontaneous nociceptive behaviours, (SNBs) in rats. Also, the SNBs induced by these agents were reduced by a non-selective mGluR antagonist or by an NMDAR antagonist. In Study 3, it was shown that intrathecal administration of a selective group I mGluR agonist produced persistent mechanical allodynia, mechanical hyperalgesia and heat hyperalgesia in rats. In Study 4, it was shown that early, but not late intrathecal administration of a relatively selective group I mGluR antagonist reduced nociceptive behaviours, in a model of neuropathic pain. In Study 5, it was shown that intrathecal administration of a selective group I mGluR antagonist reduced mechanical allodynia and cold hyperalgesia, while a selective group II mGluR agonist and a selective group III mGluR agonist only reduced mechanical allodynia and cold hyperalgesia, respectively, in the neuropathic pain model. Results from these studies first suggest that spinal group I mGluRs may be more critically involved in the development of chronic nociceptive behaviours, compared to persis
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The bee venom test : a new tonic-pain testLariviere, William R. January 1995 (has links)
The present study describes a new test of tonic pain in rats which can be used as an animal model of persistent pain. In the first experiment, the response to subcutaneous injection of various doses of bee venom into the hind paw of the rat was quantified. The second experiment investigated the effect of morphine and aspirin on the response to an intermediate dose of bee venom. Finally, the third experiment examined the response to concurrent injections of bee venom and formalin. Subcutaneous injection of bee venom produced local inflammation, marked edema, and tonic pain responses. Increasing doses of bee venom produced higher mean pain scores and increased durations of responding. Pain responses lasted up to approximately one hour and the inflammation and edema were virtually gone by 8 hours with the lower doses of bee venom tested and by 2 days with the two highest doses tested. Analgesia was produced by morphine and aspirin, indicating that the bee venom test can be used to test analgesic drugs. Concurrent administration of bee venom and formalin produced responses similar to formalin alone, with an increased duration of responding at higher intensities. The data suggest that the bee venom test is a valid animal model of experimental tonic pain.
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Characterisation of the spared nerve injury model of neuropathic pain /Erichsen, Helle Kirstein. January 2003 (has links)
Ph.D.
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The contribution of metabotropic glutamate receptors to models of persistent and chronic pain /Fisher, Kim Noël January 1998 (has links)
No description available.
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The bee venom test : a new tonic-pain testLariviere, William R. January 1995 (has links)
No description available.
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Intracellular messengers involved in nociceptive behaviours induced by intrathecal (R,S)-3,5-dihydroxyphenylglycineAmbrosini, Snijezana Sue Snez January 2003 (has links)
We investigated the role of two intracellular second messengers, extracellular signal-regulated protein kinase (ERK), and protein kinase C (PKC) in a model of persistent pain, using intrathecal (i.t) (R,S )-DHPG to induce spontaneous nociceptive behaviours (SNBs). SNBs were measured in animals that were treated with an ERK inhibitor (PD 98059), and a PKC inhibitor (GF 109203X) compared with controls. Mechanical allodynia, was measured using paw withdrawal thresholds in the von Frey test, and thermal hyperalgesia was measured using response latencies in the plantar test. In study 1, it was shown that spinal administration of PD 98059, dose-dependently decreased SNBs, and reduced mechanical allodynia and thermal hyperalgesia. In study 2, it was shown that i.t. pretreatment with the GF 109203X, reduced SNBs and thermal hyperalgesia, but not mechanical allodynia. These results suggest that both ERK and PKC are involved in SNBs and the concomitant and thermal hyperalgesia and possibly mechanical allodynia.
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Intracellular messengers involved in nociceptive behaviours induced by intrathecal (R,S)-3,5-dihydroxyphenylglycineAmbrosini, Snijezana Sue Snez January 2003 (has links)
No description available.
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Ketamine on chronic post-ischemia pain (CPIP) model of complex regional pain syndrome (CRPS) type I in Sprague-Dawley (SD) ratsLiman, Suryamin., 陳明正. January 2011 (has links)
published_or_final_version / Anaesthesiology / Master / Master of Philosophy
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