Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 4 uppsatser.

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirement for the degree of Master of Science in Epidemiology and Biostatistics. November 2017. / Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a devastating diagnosis for anyone as it is associated with a global mortality rate of about 4%, and has few therapeutic interventions that prolong survival as compared to other cancers. Frequent epidemiological reports on PDAC are available in the developed countries, but in South Africa, there is a paucity of epidemiological data on this aggressive cancer. Understanding risk factors will help to assess and develop relevant interventions for asymptomatic high-risk patient populations. Aim: To investigate and explore how various risk factors were associated with PDAC at two public academic hospitals in Johannesburg between 2013 and 2015. Method: This was a secondary unmatched case-control study to assess risk factors for developing PDAC at two public academic hospitals, namely the Chris Hani Baragwanath Academic Hospital (CHBAH) and the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). All cases of PDAC were histologically and/or cytologically confirmed. All participants were >18 years of age, including 139 cases and 139 controls. Data exported from REDCap database included patient demographics and social and medical histories. Proportions used the chi-square test and bivariate logistic regression estimated ORs between individual variables and PDAC. Multivariate logistic regression analysis investigated all possible confounders present in the data. The likelihood ratio test with a p-value of <0.20 was accepted to assimilate data fitting into the model. Results: Eighty two percent of the study population was black. The 50-59 age group accounted for 37% of the cases. Multiple logistic regressions showed the following odds ratios 95% CI and p-values for ages (i) 20-29 [0.11(0.11-1.00) p=0.05] and (ii) 50-59 [2.63(1.03-6.70) p=0.04]. As for diet, the following odds were observed (i) high white meat [0.18(0.04-0.86) p=0.03], (ii) low fish intake [2.17(1.06-4.45) p=0.03], (iii) low consumption of fried food [0.48(0.23-1.00) p=0.05] and (iv) high consumption of vegetables [0.17(0.05-0.61) p=0.007]. In terms of occupation, general workers had the following likelihood [1.79(0.93-3.45) p=0.08] of developing PDAC. Conclusion: Being 50-69 years of age and employed for longer periods than the general norm, was positively associated with PDAC. Additionally, increased consumption of vegetables and white meat was protective against PDAC, whilst a low intake of fish increased PDAC risk. Keywords: Pancreatic cancer, risk factors, epidemiology and case-control. / LG2018

Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted.

Thesis (Ph. D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed June 10, 2008). Includes bibliographical references.

A Thesis submitted to the Faculty of Health Sciences, University of Witwatersrand, in fulfilment of the requirements for the degree of Doctor of philosophy. Johannesburg, 2017. / Pancreatic cancer (PDAC) is a deadly type of cancer with almost an equal amount of new cases and deaths observed yearly. It accounts for about 7% of cancer related deaths worldwide with less than 5% of PDAC patients living up to 5 years. The lack of specific and sensitive diagnostic tests is strongly responsible for this poor statistic. The discovery of differentially expressed genes and proteins associated with PDAC is crucial to elucidating this condition and may lead to biomarker finding and further understanding of the disease. This in turn may lead to improved diagnostic tests for early diagnosis. The aim of this study was to identify novel potential biomarkers for PDAC. [No abstract provided. Information taken from summary] / MT2017

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from first page of PDF file (viewed on June 10, 2009). Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 54-62).

by Lai Bo San Paul. / "April 1997." / "Revised May 1998." / Thesis (M.D.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (p. 175-228). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstract in Chinese.