The THz region is a burgeoning field of research with applications in spectroscopy, integrated circuit fabrication, bio-medicine, and communications. Until recently, the THz region was largely unexplored, mainly due to the technical difficulties involved in making efficient and compact sources and detectors. As these challenges are addressed, the focus of research has shifted to practical applications, such as sensing and imaging. The focus of this thesis is to investigate the characterization of parallel plate waveguide multimode propagation and periodically notched resonant structures for use in sensing and material parameter extraction applications. Broadband and narrowband measurements are presented and analyzed. Measurements are compared to finite difference time domain simulations and analytic solutions that use a Fourier transform mode-matching technique. Agreement is observed between simulation and measurement of radiation patterns. Weighted estimates of individual mode analytic solutions produce equivalent radiation patterns, which allows insight into the energy coupled into each respective mode. Results show that higher order modes contribute both a greater conductive attenuation and higher coupling loss. Agreement is also observed between measurements and simulated single and periodically notched resonant structures. Results demonstrate shifting of the resonant peak with respect to changes in plate separation for the periodically notched structure. For the single notch resonator, simulations indicate the resonant peak is dependent on notch depth until the depth-to-width ratio is greater than two. This work demonstrates that multimode propagation can be identified and the amount of energy coupled into each mode may be estimated using radiation patterns. Experiments using quasi-optical time domain spectroscopic and continuous wave vector network analyzer systems in the THz region have been demonstrated. Finite difference time domain simulations have validated measurements on both systems. The results presented will advance the field of THz research by aiding in the design and analysis of sensing and material parameter extraction systems

A simplified model is developed to predict the heat and mass transfer between air and fallingilm liquid desiccant during dehumidification in a parallel-plate absorber. Compared to the second-order partial differential equations that describe fluid motion, first-order, non-coupled, ordinary differential equations are used to estimate the heat and mass transferred and explicit equations are derived from conservation principles to determine the exiting conditions of the absorber for different flow arrangements. The model uses a control volume approach that accounts for the change in desiccant film thickness and property values. The model agreed with a more complicated parallel flow model in literature. Using existing experimental data for a counterflow arrangement the model was validated over the range of input variables at the level of 8% for varying inlet desiccant flow rates and 10% for varying inlet air mass flow rates when an experimentally determined mass transfer coefficient was used in the model.

<p>The purpose of this research was to verify experimentally the buildup region dose calculation for Pinnacle³ (version 9.0), a commercial treatment planning system, commissioned and in use at the Saskatoon Cancer Center. To achieve this, buildup dose measurements using Attix parallel-plate ionization chamber and calculations by Pinnacle³, for a variety of clinical setups, were compared. The clinical setups involved 6 MV and 15 MV photon beams, open fields, enhanced dynamic wedges, physical wedges, block tray, 85, 100 and 120 cm source-to-surface distances (SSDs), and field sizes 3 x 3, 4 x 4, 5 x 5, 8 x 8, 10 x 10, 12 x 12, 15 x 15, 20 x 20, 30 x 30 cm². The dose difference (DD) and distance-to-agreement (DTA) were used to evaluate the discrepancy between measured and calculated dose values. Significant discrepancies between measured and calculated buildup dose values were observed because the modeling in Pinnacle³ is based on measurements made using a cylindrical ionization chamber. Based on the criteria of DD less than 2% or DTA less than 2 mm, 93.7% of 1,710 dose points for the 6 MV photon beam passed while for the 15 MV photon beam, 96.1% of the 2,244 dose points passed. The dose points that did not pass these criteria were mostly for open fields, block tray fields, fields with physical wedges of 15 degrees and 30 degrees and for fields with shorter source-to-surface distances. This is attributed to the high electron contamination associated with these fields. The low levels of discrepancies between measured and calculated dose values for the 15 MV beam as compared to those of the 6 MV beam need further investigations. The good agreement between measured and calculated dose values after remodeling the Electron Contamination in Pinnacle³ based on Attix chamber measurements is an indication that the Electron Contamination equation in Pinnacle³ may be adequate for modeling of electron contamination in the buildup dose region. The disagreement between Attix chamber and EBT 2 film measured buildup dose values was less than 3% for 89.9% of the buildup dose measurements compared. It is recommended to use a good parallel plate ionization chamber, such as the Attix chamber, for measurements in the buildup region.</p>

<p>The purpose of this research was to verify experimentally the buildup region dose calculation for Pinnacle³ (version 9.0), a commercial treatment planning system, commissioned and in use at the Saskatoon Cancer Center. To achieve this, buildup dose measurements using Attix parallel-plate ionization chamber and calculations by Pinnacle³, for a variety of clinical setups, were compared. The clinical setups involved 6 MV and 15 MV photon beams, open fields, enhanced dynamic wedges, physical wedges, block tray, 85, 100 and 120 cm source-to-surface distances (SSDs), and field sizes 3 x 3, 4 x 4, 5 x 5, 8 x 8, 10 x 10, 12 x 12, 15 x 15, 20 x 20, 30 x 30 cm². The dose difference (DD) and distance-to-agreement (DTA) were used to evaluate the discrepancy between measured and calculated dose values. Significant discrepancies between measured and calculated buildup dose values were observed because the modeling in Pinnacle³ is based on measurements made using a cylindrical ionization chamber. Based on the criteria of DD less than 2% or DTA less than 2 mm, 93.7% of 1,710 dose points for the 6 MV photon beam passed while for the 15 MV photon beam, 96.1% of the 2,244 dose points passed. The dose points that did not pass these criteria were mostly for open fields, block tray fields, fields with physical wedges of 15 degrees and 30 degrees and for fields with shorter source-to-surface distances. This is attributed to the high electron contamination associated with these fields. The low levels of discrepancies between measured and calculated dose values for the 15 MV beam as compared to those of the 6 MV beam need further investigations. The good agreement between measured and calculated dose values after remodeling the Electron Contamination in Pinnacle³ based on Attix chamber measurements is an indication that the Electron Contamination equation in Pinnacle³ may be adequate for modeling of electron contamination in the buildup dose region. The disagreement between Attix chamber and EBT 2 film measured buildup dose values was less than 3% for 89.9% of the buildup dose measurements compared. It is recommended to use a good parallel plate ionization chamber, such as the Attix chamber, for measurements in the buildup region.</p>

Since integrity and functions of vascular endothelial cells are greatly affected by shear stress, a variety of in vitro systems to subject endothelial cells under precisely controlled fluid conditions has been developed. Complicated designs of the conventional flow devices, however, have impeded such implementation. In the present study, we designed and developed a novel parallel-plate flow chamber (PPFC). It consists of multiple layers of different materials to adjust the required geometries of the chamber and provide a wide span of biomedical research applications. Because the chamber stacks separate layers to constitute the flow channel, different pieces can be easily removed or replaced. Moreover, the multilayer design only requires 2D cutting, which is easier and faster to manufacture. It is also capable of accepting up to four glass slides facing each other so that the flow within the channel is exclusively formed by endothelial cells. Furthermore, it minimizes the pressure loss across the chamber while maximizing the effective area of endothelial cells up to 96 cm2. Results from mathematical analysis and dye injection experiments showed that a uniform magnitude of shear stress is applied throughout the entire surface of endothelial cells. In addition, the morphological changes and attenuated gene expression of pro-inflammatory mediators were observed in endothelial cells exposed to the physiologically relevant shear stress. These findings indicate that our newly designed PPFC can provide a better in vitro system for versatile applications of biomedical research. The reperfusion of blood flow occurred in a number of conditions such as stroke and organ transplantation immensely augments tissue injury and can cause more severe damage than prolonged ischemia. The injuries caused by cessation and reperfusion of blood flow are closely related to the inflammatory reactions involving in endothelium-leukocyte cascade responding to a shear stress exerted by the flow. Shear stress is also known to play an important role in human chronic diseases including atherosclerosis, neurological disorders, and cancer metastasis. Therefore, it is important to investigate the transmission of mechanical stimuli such as shear stress to various complex endothelial cell signaling pathways which process as a whole is often referred as mechanotransduction. Shear stress-mediated signaling pathways have been known to trigger endothelial cell responses and contribute to the pathophysiology of human vascular diseases. The present study was designed to apply the novel PPFC to biomedical research, especially ischemia/reperfusion injury. The changes in mRNA and protein expression of inflammatory mediators in endothelial cells were analyzed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. RBE4 and HMEC-1 cells were either maintained in continuous laminar flow condition (Normal Flow) or subjected to 1 h of flow cessation followed by reperfusion of flow (Ischemia/Reperfusion) for 24 h. Ischemia/Reperfusion significantly up-regulated expression of inflammatory mediators, such as IL-6, MCP-1, ICAM-1, VCAM-1, and E-selectin, in microvascular endothelial cells. Furthermore, antioxidant pyrrolidine dithiocarbamate (PDTC) significantly attenuated ischemia/reperfusion-induced overexpression of pro-inflammatory mediators. These data indicates that our newly designed PPFC provide a better in vitro system for versatile applications of biomedical research. / Master of Science

Cure time is often the bottleneck of composite manufacturing processes, therefore it is important to understand the cure of today's thermosetting adhesives. This research attempts to characterize the cure rate of two commercial phenol-formaldehyde adhesives. Two methods are used, parallel-plate rheometry and dielectric spectroscopy. Viscosity data from a parallel-plate rheometer may be used to track the advance of polymerization as a function of temperature. This data can then be used to optimize press conditions and reduce production times and costs. The research will further examine resin cure through dielectric analysis; such a technique could monitor resin cure directly and in real-time press situations. Hot-pressing processes could conceivably no longer require a set press schedule; instead they would be individually set based on dielectric data for every press batch. Such a system may lead to a more efficient and uniform product because press times could be based on individual press cycles instead of entire product lines. A more likely scenario, however, is the use of in situ adhesive cure monitoring for troubleshooting or press schedule development. This research characterized the cure of two phenol-formaldehyde resins using parallel-plate rheometry, fringe-field dielectric analysis, and parallel-plate dielectric analysis. The general shape of the storage modulus vs. time curve and the gel and vitrification points in a temperature ramp were found. Both dielectric analysis techniques were able to characterize trends in the resin cure and detect points such as vitrification. The two techniques were also found to be comparable when the cure profiles of similar conditions were examined. / Master of Science

Thermoacoustic devices are a group of systems that make use of the thermoacoustic effect to achieve an energy conversion between thermal and acoustic energy. The thermoacoustic effect occurs when a solid boundary is introduced into an acoustic field, and a non-zero net heat transportation takes place while the net mass transfer remains null. Thermoacoustic technologies are gaining an increasing research interest because of their potential applications for building alternative prime movers or heat pumps which do not use working fluids causing environmental damage and require very little maintenance due to their lack of moving part. However, the operation of this type of system is yet to be fully understood: fluid flow and heat transfer processes within the system components such as thermoacoustic stacks and heat exchangers still require a lot of attention. The performance of the system working with relatively low amplitude acoustic wave can be predicted by the linear thermoacoustic theory, which is already well developed. However, a high amplitude acoustic wave is usually required in order to achieve high power density or high power output. Unfortunately, the performance of such systems can be seriously degraded due to nonlinear effects, such as turbulence, minor loss or high proportion of harmonics. The lack of understanding of these effects impedes the design and construction of high efficiency systems. The work described in this thesis is focused on the study of flow phenomena taking place around parallel plate stack placed in a standing wave thermoacoustic resonator, by using advanced flow diagnostics techniques such as particle image velocimetry (PIV) and hot wire anemometry (HWA). In order to carry out the experimental study, a standing wave thermoacoustic device working at relatively low frequency of 13.1Hz was designed, commissioned and tested. The frequency response of this device was carefully investigated and compared with the analytical results using linear acoustic equations and a linear model of the loudspeaker. A further comparison with the analytical results obtained with the modelling tool DeltaEC (Design Environment for Low-amplitude Thermoacoustic Energy Conversion) was also presented. The resonator was driven from low to large pressure amplitudes with drive ratios up to 10%. A good agreement is obtained for small amplitudes, but the discrepancies become larger when the driving amplitude is increased. The analysis reveals that the large discrepancy at high amplitude can be attributed to minor losses. Following the above preliminary work, a more comprehensive study of the flow field around parallel-plate stacks was conducted by means of PIV and HWA. It was shown that the flow around the two studied parallel-plate stacks exhibits rather complicated flow features when the amplitude of the acoustic oscillation varies. Symmetrical and asymmetrical vortex shedding phenomena are observed and two distinct modes of generating 'vortex streets' are identified. It shown that a velocity related parameter such as the Reynolds number, defined on the plate thickness and the velocity amplitude at the entrance to the stack, and a geometrical parameter are not sufficient to define the flow characteristics in this type of flow problem. It is also proposed to introduce an extra frequency related parameter such as the Keulegan-Carpenter number (KC) and to carry out a similarity analysis in order to understand better the physics behind the flow phenomena and their controlling parameters. Typical ensemble-averaged velocity fields are used in the analysis above. However, the detailed flow features obtained from the ensemble averaged flow fields and the instantaneous flow fields could be different in a substantial way. The flow behaviour, its kinematics, dynamics and scales of turbulence, therefore are further investigated by using the classical Reynolds decomposition to separate the instantaneous velocity fields into ensemble-averaged mean velocity fields and fluctuations in a set of predetermined phases within an oscillation cycle. The mean velocity field and the fluctuation intensity distributions are investigated over the acoustic oscillation cycle. By using fast Fourier transform (FFT) spatial filtering techniques, the velocity fluctuation is further divided into large- and small-scale fluctuations, and their physical significance is discussed. The physics behind the flow phenomena are further studied by carrying out an analysis of the wake flow during the ejection part of the flow cycle, where either closed re-circulating vortices or alternating vortex shedding can be observed. A similarity analysis of the governing Navier-Stokes equations is then undertaken in order to derive the similarity criteria governing the wake flow behaviour. Similarity numbers including two types of Reynolds number, the KC number and a non-dimensional stack configuration parameter are considered. The influence of these parameters on the flow behaviour is discussed by investigating the experimental data obtained, along with additional data from literature.

Portland cement concrete (PCC) structures deteriorate with age and need to be maintained or replaced. Early detection of deterioration in PCC (e.g., alkali-silica reaction, freeze/thaw damage or chloride presence) can lead to significant reductions in maintenance costs. Portland cement concrete can be nondestructively evaluated by electrically characterizing its complex dielectric constant in a laboratory setting. A parallel-plate capacitor operating in the frequency range of 0.1 to 40.1 MHz was developed at Virginia Tech for this purpose. While useful in research, this approach is not practical for field implementation. In this study, a capacitor probe was designed and fabricated to determine the in-situ dielectric properties of PCC over a frequency range of 2.0 to 20.0 MHz. It is modeled after the parallel-plate capacitor in that it consists of two conducting plates with a known separation. The conducting plates are flexible, which allows them to conform to different geometric shapes. Prior to PCC testing, measurements were conducted to determine the validity of such a system by testing specimens possessing known dielectric properties (Teflon). Portland cement concrete specimens were cast (of sufficient size to prevent edge diffraction of the electromagnetic waves) having two different air contents, two void thicknesses, and two void depths (from the specimen's surface). Two specimens were cast for each parameter and their results were averaged. The dielectric properties over curing time were measured for all specimens, using the capacitor probe and the parallel-plate capacitor. The capacitor probe showed a decrease in dielectric constant with increasing curing time and/or air content. In addition to measuring dielectric properties accurately and monitoring the curing process, the capacitor probe was also found to detect the presence and relative depth of air voids, however, determining air void thickness was difficult. / Master of Science

As the amount of study into the terahertz (THz) region of the electromagnetic spectrum steadily increases, the parallel plate waveguide has emerged as a simple and effective fixture to perform many experiments. The ability to concentrate THz radiation into a small area or volume enables us to analyze smaller samples and perform more repeatable measurements, which is essential for future research. While the fundamental physics of PPW transmission are understood mathematically, the practical knowledge of building such a fixture for the THz domain and taking measurements on it with a real system needs to be built up through experience. In this thesis, multiple PPW configurations are built and tested. These include waveguides of different lengths and opening heights, using lenses and antennas to focus and collect radiation from the input and output, and different amounts of polish on the waveguide surface. A basic resonator structure is also built and measured as a proof of concept for future research. The two most useful propagation modes through the waveguide, the lowest order transverse magnetic (TEM) and transverse electric (TE) modes, were characterized on all of the setups. Additionally, a flexible fixture was designed and measured which will allow future work in the THz field to be much more reliable and repeatable.

L'impression par transfert, une technique utilisée pour transférer divers matériaux tels que des molécules d'ADN, de la résine photosensible ou des nanofils semi-conducteurs, s'est dernièrement révélée utile pour la réalisation de structures de silicium statiques sous le nom de micro-maçonnerie. L'étude présentée ici explore le potentiel de la technique de micro-maçonnerie pour la fabrication de résonateurs MEMS. Dans ce but, des microplaques de silicium ont été transférées sur des couches d'oxyde avec cavités intégrées à l'aide de timbres de polymère afin de créer des structures de type plaques suspendues. Le comportement dynamique de ces structures passives a été étudié sous pression atmosphérique et sous vide en utilisant une excitation externe par pastille piézo-électrique mais aussi le bruit thermomécanique. Par la suite, des résonateurs MEMS actifs, à actionnement électrostatique et détection capacitive intégrés, ont été fabriqués en utilisant des étapes supplémentaires de fabrication après impression. Ces dispositifs ont été caractérisés sous pression atmosphérique. Les facteurs de qualité intrinsèques des dispositifs fabriqués ont été évalués à 3000, ce qui est suffisant pour les applications de mesure à pression atmosphérique et en milieu liquide. Nous avons démontré que, puisque l'adhérence entre la plaque et l'oxyde est suffisamment forte pour empêcher une diaphonie mécanique entre les différentes cavités d'une même base, plusieurs résonateurs peuvent être facilement réalisés en une seule étape d'impression. Ce travail de thèse montre que la micro-maçonnerie est une technique simple et efficace pour la réalisation de résonateurs MEMS actifs de type plaque à cavité scellée. / Lately, transfer printing, a technique that is used to transfer diverse materials such as DNA molecules, photoresist, or semiconductor nanowires, has been proven useful for the fabrication of various static silicon structures under the name micro-masonry. The present study explores the suitability of the micro-masonry technique to fabricate MEMS resonators. To this aim, silicon microplates were transfer-printed by microtip polymer stamps onto dedicated oxide bases with integrated cavities in order to create suspended plate structures. The dynamic behavior of fabricated passive structures was studied under atmospheric pressure and vacuum using both external piezo-actuation and thermomechanical noise. Then, active MEMS resonators with integrated electrostatic actuation and capacitive sensing were fabricated using additional post-processing steps. These devices were fully characterized under atmospheric pressure. The intrinsic Q factor of fabricated devices is in the range of 3000, which is sufficient for practical sensing applications in atmospheric pressure and liquid. We have demonstrated that since the bonding between the plate and the device is rigid enough to prevent mechanical crosstalk between different cavities in the same base, multiple resonators can be conveniently realized in a single printing step. This thesis work shows that micro-masonry is a powerful technique for the simple fabrication of sealed MEMS plate resonators.