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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The effect of haloxon and thiabendazole on the free-living stages of Haemonchus contortus

McCallister, Gary 01 August 1973 (has links)
This study was undertaken to determine the effect of thiabendazole and haloxon on the free-living stages of Haemonchus contortus and to determine the suitability of the free-living stages for their use in primary drug evaluation for chemotherapy or for chemical control of free-living stages. Cleaned unembryonated ova, embryonated ova, first-, second-, third-, and exsheathed third-stage larvae were exposed to suspensions of 5.0%, 1.0%, 0.5%, 0.25%, 0.12%, 0.05%, and water soluble concentrations of each drug for exposure times of 0.25, 0.50, 1.0, 2.0, 4.0, 8.0, and 16.0 hours at pH 7.0 and 25° C. Survival was assessed by observing any subsequent development or motility. Thiabendazole was partially ovicidal to unembryonated ova at water soluble levels and after exposure of only 15 minutes. Exposure of longer than 4 hours was 100% lethal. No other stages were effected by thiabendazole. Haloxon was ineffective against all stages tested.

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