Thesis (Ph. D.)--University of Hong Kong, 1989.

The effect of parathormone (Lilly) on the total mineral content of bones and muscles (percentage of ash per gram of dry tissue) was used as a measure of hormone activity. Goldfish, frogs, mice, chicks and pigeons were compared. The effect of the parathormone varied with the species. Goldfish showed no response even with massive doses at high temperatures. Frogs, mice and chicks showed a rise in percent bone ash. In chicks an initial rise was followed by a depression. Mice showed the greatest increase in bone ash. Frogs were less responsive than mice but more responsive than chicks. Pigeons showed a distinct softening of the bones. There was no change in muscle ash in any animals except pigeons, which showed a distinct rise. The parathyroid mechanism, whether it acts directly on bones or kidneys, does not seem to operate in aquatic animals. / Science, Faculty of / Zoology, Department of / Graduate

Note:

published_or_final_version / Medicine / Doctoral / Doctor of Philosophy

No description available.

Diss. (sammanfattning) Uppsala : Univ., 2004. / Härtill 4 uppsatser.

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 38-46). Also available via the Internet.

Osterix (Osx) is a transcription factor required for osteoblast differentiation and bone formation. We previously demonstrated that continuous parathyroid hormone (PTH) treatment inhibited Osx expression in murine calvaria and osteoblastic UMR106-01 cells through the regulation of two regions on the Osx promoter. Mutational analysis of transcription factor elements within these regions revealed two "Sp-sites" were vital for Osx promoter activity. Blockage of these Sp-sites with Mithramycin A demonstrated their importance for Osx expression. Osx bound to its own promoter at these sites, while PTH treatment inhibited this association. PTH regulation of Osx expression in vivo was investigated in mice by: daily injection of PTH for 3 days, continuous infusion of PTH from osmotic pumps for 14 days, or mice fed a calcium-deficient diet for 21 days. Osx expression was decreased by daily injection, while Osx expression was stimulated in mice receiving continuous PTH infusion and mice fed a calcium-deficient diet.

Osterix (Osx) is a transcription factor required for osteoblast differentiation and bone formation. We previously demonstrated that continuous parathyroid hormone (PTH) treatment inhibited Osx expression in murine calvaria and osteoblastic UMR106-01 cells through the regulation of two regions on the Osx promoter. Mutational analysis of transcription factor elements within these regions revealed two "Sp-sites" were vital for Osx promoter activity. Blockage of these Sp-sites with Mithramycin A demonstrated their importance for Osx expression. Osx bound to its own promoter at these sites, while PTH treatment inhibited this association. PTH regulation of Osx expression in vivo was investigated in mice by: daily injection of PTH for 3 days, continuous infusion of PTH from osmotic pumps for 14 days, or mice fed a calcium-deficient diet for 21 days. Osx expression was decreased by daily injection, while Osx expression was stimulated in mice receiving continuous PTH infusion and mice fed a calcium-deficient diet.

Zugl.: Giessen, Universiẗat, Diss., 2008.