The present study examines the relationship between acculturation, parental control, and psychological adjustment among adult first and second-generation Asian Indian women who have immigrated, or whose parents have immigrated to the United States, from the Indian state of Kerala. Data from 73 participants indicate second-generation immigrants report poorer psychological adjustment than do their counterparts. Additionally, regression analyses reveal discomfort towards Kerala culture significantly predicts depressive symptoms, while high maternal control predicts self-esteem. Qualitative data were collected to provide richer understanding of immigrants' adaptation to the U.S. Implications of this research may impact mental health practitioners' ability to improve quality of life with Asian Indian women from Kerala.