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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"parenteral formulation"" "subject:"parenterale formulation""

1

COUNTERMEASURES FOR CYANIDE: ORGANOMETALLICS AS NOVEL CYANIDE SCAVENGERS

Matthew Mark Behymer (16558242) 17 July 2023 (has links)
<p>The objective for this work is to identify and develop an intramuscularly delivered cyanide scavenger. This dissertation outlines in vitro methods which are used to evaluate platinum-based complexes for the potential to scavenge cyanide. Examples of the in vitro techniques used are HPLC, UV-Vis and an ion-selective electrode as orthogonal strategies to monitor cyanide scavenging. Intramuscular formulations for the active platinum-based scavengers are prepared and evaluated for stability. Subsequently, the formulations are tested by collaborating labs for in vivo efficacy. In addition, Sprague Dawley rat studies are employed to investigate the potential toxicity for several platinum complexes. Taken together, this dissertation outlines a short list of novel platinum-based cyanide scavengers as potential alternatives to legacy cobalt-based scavengers. </p>
Pharmaceutical sciences
toxicity
Organometallic Chemistry
HPLC
UV-Vis
Cyanide
Platinum
Kinetics
Nephrotoxicity
Stability
Pharmaceutics
Parenteral formulation

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