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The present research examines the pathological changes and taphonomic alterations of buried human skeletal remains discovered in a burial feature underneath a construction site in a neighborhood house in Winchester, Massachusetts. Artifact association places the burial of these remains around the mid 1800s. Pathological changes were observed based on the presence of bone formation or destruction. The manifestations of pathological change observed for were related to or consistent with joint disease, infectious diseases, metabolic disorders, congenital abnormalities, dental disease, and neoplastic conditions. Taphonomic profiles of buried remains display certain characteristics that can be used to make comparisons to other known burial types, specifically traditional cemetery burials. The characteristics observed for to create the taphonomic profile were soil and mineral staining, bone condition and preservation, plant adherence and/or damage, postmortem damage, and the presence of coffin artifacts. The author hypothesized that the current sample of human skeletal remains from the Winchester Site would display pathological changes consistent with individuals from marginalized populations of the nineteenth century. The most prevalent pathological changes in the sample were those related to osteoarthritis (OA) and infection. The vertebral elements were most affected by OA, at 24.0% on the vertebral bodies and 17.5% on the vertebral facets. Of the remaining elements scored for OA, only 7.1% showed characteristics. Infection was observable on 10.9% of the postcranial elements, with the fibulae being the most affected, at 20.9%, followed by the tibiae at 18.3% and the clavicles at 16.1%. There were more cases of sclerotic bone, which indicated that the healing process started prior to death. There were only 11 cases of antemortem trauma that were observed to be either in the process of healing or already healed, as well as 2 cases of healed amputations of two proximal row pedal phalanges. Dentition was most affected by calculus at 33.3%, and had little instances of linear enamel hypoplasias. Other miscellaneous pathological changes were also observed, including Schmorl’s nodes, PH/CO, HFI, possible neoplasms, possible tuberculosis, and exostoses of the mouth. It was also hypothesized that the skeletal remains would display a different taphonomic profile compared to previously researched profiles of anatomized and cemetery remains. There is ubiquitous soil staining throughout the sample, postmortem damage at 69.4%, moderate cortical erosion at 15.7%, slight plant root adherence at 8.3%, and low mineral staining at 5.3%. There is a lack of anatomical hardware present throughout the remains, which indicates that the remains were not used for anatomical teaching. There is an abnormal pink stain on 1.0% of the skeletal remains, possibly the result of a historical embalming technique that used mercury. The analysis of the skeletal remains from the Winchester Site supported the hypothesis that the remains would display pathological changes consistent with marginalized populations. The author compared the Winchester Site to sites that reported having anatomized remains of marginalized individuals, specifically sites that were used as medical waste sites, poorhouses, and almshouses. The analysis of the skeletal remains also supported the hypothesis that the remains would display a taphonomic profile more consistent with cemetery remains buried directly in the soil and secondarily determined that the site was likely used as a medical waste site of anatomized remains. The analysis of the Winchester Site also confirmed that the remains did not display a taphonomic profile related to coffin cemetery remains or remains that have been prepared and used for anatomical teaching.