Les phases de transitions entre les différentes stratégies de prise en charge de l'insuffisance rénale chronique terminale peuvent être associées à une augmentation de la morbidité et de la mortalité lorsqu’elles ne sont pas anticipées. Il faut donc pouvoir définir des trajectoires de patient et faire en sorte de maîtriser les changements d’état afin d’améliorer la prise en charge du patient insuffisant rénal chronique. Cela ne peut être atteint sans une phase exploratoire préalable visant à étudier les phases de transition du parcours de soins intégrés. L’objectif de ce travail était donc d’étudier trois transitions présentes dans le parcours de soins du patient atteint d’insuffisance rénale chronique.Nous avons montré que chez le patient qui débute la dialyse péritonéale, le temps passé au préalable dans un autre traitement de suppléance, que ce soit en hémodialyse ou en transplantation rénale, peut précocement impacter son devenir dans la technique. Cette importance du traitement antérieur renforce notre conviction qu’il faut avoir une vision globale et intégrée de la prise en charge du patient insuffisant rénal chronique terminal. De même, la survenue d’une péritonite dans les premiers mois en dialyse péritonéale est associée à l’arrêt précoce de la technique. Il est donc indispensable à la prise en charge initiale et au cours des premiers mois de traitement en dialyse péritonéale de s’interroger sur le risque de transfert précoce en hémodialyse du patient et sur la nécessité de lui créer une fistule artério-veineuse. Nous avons également rapporté le fait que les infections liées à la fistule en dialyse hors centre sont des événements relativement peu fréquents. Cependant, une approche différente de ces infections, en distinguant le risque de première infection et le risque de récidive infectieuse chez un patient, permettra de diminuer la fréquence de ces événements responsables de transition non programmée entre les différentes structures de dialyse. Enfin, nous avons choisi d’étudier la transition entre stade V de l’insuffisance rénale et le traitement par dialyse dans la population des patients atteints de cancer. Nous avons montré que l’incidence de la dialyse dans cette population n’est pas plus importante que dans la population générale. La survie en dialyse de ces sujets semble également comparable à celle des dialysés sans cancer diagnostiqué. Nos résultats suggèrent que seuls les patients avec un cancer en bonne condition générale ont la possibilité d’être traité par dialyse chronique. Il existe un réel rationnel scientifique à considérer le parcours de soins du patient insuffisant rénal chronique stade V comme un parcours intégré, comprenant plusieurs états et de nombreuses phases de transition, qui doivent être explorées finement tout en tenant compte de l’ensemble de la trajectoire du patient. / Transitions between treatment strategies in chronic kidney disease are often not prepared and can lead to morbidity and mortality. It is necessary to anticipate these transitions to improve patients outcomes and health care organisation. We aimed at studying three pathways observed in the career of chronic kidney disease patients.We have shown that patients treated by hemodialysis before peritoneal dialysis start and failed transplant patients had a higher risk of early peritoneal dialysis failure. Early peritonitis was also associated with a higher risk of early technical failure. It is therefore important to evaluate the necessity to create an arterio-venous fistula in peritoneal dialysis patients during the first months on dialysis, to avoid transfer in hemodialysis on a central venous catheter.We reported that the rate of arterio-venous fistula infections in satellite dialysis units was low. However, it seems necessary to distinguish the risk for having a first infection and the risk for having a relapse of infection. This consideration can help decreasing the number of fallback between stallite units and hospital dialysis centers.Finally, we studied transition between end-stage renal disease and dialysis in cancer patients. We showed that incidence of chronic dialysis initiation in that population was not higher then the one observed in the general population. Survival in dialysis was not different in cancer patients compared to matched patients without malignancy. We can hypothesise that only cancer patients in good condition are proposed for dialysis programs.It is necessary to consider the chronic kidney disease patients' care as an integrated care program, with transitions between treatment strategies that can be improved and anticipated.

Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-22T12:30:27Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_SimoneBarbosaPereira.pdf: 1911161 bytes, checksum: 8274b42d34b16d295141ae46b63f2ed9 (MD5) / Made available in DSpace on 2018-08-22T12:30:27Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_SimoneBarbosaPereira.pdf: 1911161 bytes, checksum: 8274b42d34b16d295141ae46b63f2ed9 (MD5) Previous issue date: 2016-12-20 / Good practices in childbirth and birth care do not constitute a new theme. They have gained notoriety due to the excessive use of invasive technologies and a high number of cesarean sections, in which Brazil ranks first in the world scale. One of the drivers of these changes was the launch by the World Health Organization in 1985 of the document entitled "Appropriate technologies for childbirth and birth". This document has promoted the adoption of good practices in care delivery and birth, capable of breaking with traditional models of intervention at delivery and birth, through new methodologies and intervention technologies aimed at the humanization of childbirth. Based on this proposal, the present study aimed as its general objective: To implement the good practices of attention to childbirth and birth, recommended by the World Health Organization, in a medium-sized Hospital Obstetric Unit. As specific objectives, this study considered: Know the professionals' perception professionals of an obstetric hospital unit on the good practices of attention to childbirth and birth, recommended by the World Health Organization; and, Describe the construction and validation steps of a construct of good practices of attention to childbirth and birth, to be implemented in an Obstetric Unit of habitual risk. In order to meet the first specific objective, a qualitative research was carried out, using the focal group technique, with the participation of the multidisciplinary team of the Obstetric Unit of habitual risk, of a medium-sized institution, from April to June 2016. The second specific objective was taken from a methodological survey, carried out between August and October 2016, with the participation of 12 judges from the obstetric area, national level, between the first and second round Delphi. From the data resulting from the first specific objective and codified by content analysis, three thematic categories emerged: good practices and their meanings; from the biological character to the singular and multidimensional care; from the punctual and fragmented conception to the network of attention to childbirth and birth. It was concluded that good practices in childbirth care and birth, in addition to making it possible to rethink the obstetric model and contribute to the organization of the maternal and child health care network, stimulate the role of women in their multiple dimensions. In response to the second specific objective, was obtained, in the judges' analysis, a return of 12 instruments evaluated in the first round and seven instruments in the second round Delphi. In the first round, significant suggestions for changes were made in relation to the items of the dimensions of the construct, in which the judges presented convergences in relation to the mission, vision and values, but suggested changes in the item "assignments of each professional in the team". The construct was considered valid, both in content and appearance, and could contribute to subsidize good practices of attention to childbirth care and birth in local and national territory. It is concluded that, besides the governmental initiatives, it is necessary that the health professionals are responsible for and assume the good practices of attention to childbirth and birth as a possibility of transformation of the obstetric model. As a way of broadening the reflections and qualifying the good practices of attention to childbirth and birth at the Obstetric Unit, the origin institution of the principal researcher, she presented to the managers and multi professional team the validated construct, in days and at times previously scheduled. In addition, a graphical representation of the Construct of Good Practices of Attention to Childbirth and Birth, validated by the Judges of the obstetric area, was prepared, which will be exposed at the main entrance of the Obstetric Unit in question. / As boas práticas de atenção ao parto e ao nascimento não se constituem em temática nova. Elas ganharam notoriedade pelo uso excessivo das tecnologias invasivas e elevado número de cesarianas, nas quais o Brasil figura em primeiro lugar na escala mundial. Um dos propulsores dessas mudanças foi o lançamento, pela Organização Mundial da Saúde, no ano de 1985, do documento “Tecnologias apropriadas para o Parto e Nascimento”. Este documento impulsionou a adoção de boas práticas na atenção ao parto e ao nascimento, capazes de romper com modelos tradicionais de intervenção ao parto e ao nascimento, por meio de novas metodologias e tecnologias de intervenção voltadas para a humanização do parto. Com base nesta aposta, o presente estudo teve como objetivo geral: Implementar as boas práticas de atenção ao parto e ao nascimento, preconizadas pela Organização Mundial da Saúde, em uma Unidade Obstétrica Hospitalar de médio porte. Como objetivos específicos este estudo considerou: Conhecer a percepção dos profissionais de saúde de uma unidade hospitalar obstétrica sobre as boas práticas de atenção ao parto e ao nascimento, preconizadas pela Organização Mundial da Saúde; e, Descrever as etapas de construção e de validação de um construto de boas práticas de atenção ao parto e ao nascimento, a ser implementado em uma Unidade Obstétrica de risco habitual. Para atender ao primeiro objetivo específico foi realizada uma pesquisa qualitativa, por meio da técnica de grupo focal, com a participação da equipe multiprofissional da Unidade Obstétrica de risco habitual, de uma instituição de médio porte, no período de abril a junho de 2016. O segundo objetivo específico foi atendido a partir de uma pesquisa metodológica, realizada entre os meses de agosto e outubro de 2016, com a participação de 12 juízes da área obstétrica, de âmbito nacional, entre a primeira e a segunda rodada Delphi. Dos dados resultantes do primeiro objetivo específico e codificados pela análise de conteúdo resultaram três categorias temáticas: boas práticas e seus significados; do caráter biológico ao cuidado singular e multidimensional; da concepção pontual e fragmentada à rede de atenção ao parto e ao nascimento. Concluiu-se que as boas práticas de atenção ao parto e ao nascimento, além de possibilitarem o repensar do modelo obstétrico e contribuírem na organização da rede de atenção à saúde materno infantil, estimulam o protagonismo da mulher em suas múltiplas dimensões. Em resposta ao segundo objetivo específico obteve-se, na análise dos juízes, um retorno de 12 instrumentos avaliados na primeira rodada e sete instrumentos, na segunda rodada Delphi. Na primeira rodada foram realizadas sugestões significativas de mudanças em relação aos itens das dimensões do construto, nos quais os juízes apresentaram convergências em relação à missão, à visão e aos valores, mas, sugeriram mudanças no item “atribuições de cada profissional na equipe”. O construto foi considerado válido, tanto em conteúdo quanto em aparência, e poderá contribuir para subsidiar as boas práticas de atenção ao parto e ao nascimento em âmbito local e em território nacional. Considera-se que, para além das iniciativas governamentais, é preciso que os profissionais de saúde se corresponsabilizem e assumam as boas práticas de atenção ao parto e ao nascimento como possibilidade de transformação do modelo obstétrico. Como forma de ampliar as reflexões e qualificar as boas práticas de atenção ao parto e ao nascimento na Unidade Obstétrica, instituição de origem da pesquisadora principal, a mesma apresentou para os dirigentes e equipe multiprofissional o construto validado, em dias e horários previamente agendados. Salienta-se, enfim, que foi confeccionada uma representação gráfica do Construto de Boas Práticas de Atenção ao Parto e ao Nascimento, validado pelos Juízes da área obstétrica, o qual ficará exposto na entrada principal da Unidade Obstétrica em questão.