Thesis (BHSc--Health Science) -- Auckland University of Technology, 2004. / Also held in print (91 leaves, 30 cm.) in Akoranga Theses Collection (T 618.9280475 BIR)

THESIS (D.N.P. (Doctor of Nursing Practice))--School of Nursing, University of San Francisco, 2009. / Title from running header of part one. Converted to PDF files from various formats. Includes bibliographical references.

Objectives: 1) To describe the state of the evidence for interventions in pediatric migraine, 2) to survey experts regarding non-inferiority margins in migraine research and 3) to design a clinical trial in this area of research. Methods: A systematic review was carried out to identify randomized, placebo-controlled trials of pharmaceutical and nutraceutical interventions used to prevent migraine in children and adolescents, using Cochrane methods. Secondly, neurologists with expertise in Headache Medicine were invited to participate in a survey regarding their opinions on non-inferiority margins for outcomes used in clinical trials of migraine interventions. Thirdly, a protocol was written for a three-arm, parallel-group, randomized trial comparing the efficacy and safety of topiramate, levetiracetam and placebo for the prophylaxis of pediatric migraine. Results: The systematic review identified 19 articles of 12 interventions for pediatric migraine. The quality of the evidence was poor and few conclusions could be made. Ninety-nine eligible respondents completed the survey and non-inferiority margins for six outcomes were determined. A randomized controlled trial protocol was developed to determine if topiramate and levetiracetam are superior to placebo, and if levetiracetam is non-inferior to topiramate for the prevention of migraines in children and adolescents. Conclusions: It is hoped that the results of this thesis can be applied to further the evidence in this area of clinical research.

Access to abstract permanently restricted to Ball State community only. / Access to thesis permanently restricted to Ball State community only. / Department of Educational Psychology

Thesis (M.A.)--Northern Kentucky University, 2008. / Made available through ProQuest. Publication number: AAT 1450372. ProQuest document ID: 1490083611. Includes bibliographical references (p. 44-46)

Thesis (Ph. D.)--University of California, San Diego, 2006. / Title from first page of PDF file (viewed September 20, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

Orientador: Gimol Bensaquen Perosa / Banca: Niura Aparecida Ribeiro de Moura Padula / Banca: Cristiane Mendes Chiloffi / Banca: Maria dalva de Barros Carvalho / Banca: Sandra Marisa Pelloso / Resumo: A epilepsia é um dos transtornos crônicos mais comuns na infância. Tradicionalmente, o tratamento médico preocupou-se com o controle das crises e que a medicação tivesse o mínimo de efeitos adversos. Em anos recentes, estudos mostram que o impacto do quadro clinico e das medicações estende-se muito além do domínio físico, podendo acarretar prejuízos a nível social, cognitivo e comportamental. Agregou-se a pratica clínica, a avaliação da qualidade de vida das crianças e de seus cuidadores, com o objetivo de melhorar o bem estar dos pacientes e da família. O presente estudo teve por objetivo avaliar a qualidade de vida de crianças e adolescentes com epilepsia na percepção do cuidador e da criança e identificar possíveis fatores de risco e proteção. Foram selecionadas 52 díades, criança/cuidador, que frequentavam o Ambulatório de Neurologia e preenchiam os critérios de inclusão. Os participantes responderam aos seguintes instrumentos: Questionário de Avaliação de Qualidade de Vida em Crianças e Adolescentes (AUQEI), Qualidade de Vida da Criança Epiléptica (QVCE 50), Escala de Impacto das Doenças na Infância (ICIS), Escala de Modos de Enfrentamento (EMEP) e o Inventário de Sobrecarga de Zarit (ZBI). Após a correção dos testes foi realizada analise estatística descritiva e, num segundo momento, os dados receberam tratamento estatístico inferencial, incluindo analise de predição. Os participantes tinham idade que variava de 4 a 12 anos, 80,8% frequentavam a escola regular e aproximadamente a metade era do sexo masculino, com 0 a 4 anos de estudo. O quadro mais recorrente foi de epilepsia generalizada; 57,7% dos sujeitos tinham crises que se iniciaram antes dos 4 anos de idade e 36,5% tinham crises diárias. A grande maioria das crises durava de 0 a 10 minutos e a maioria dos sujeitos fazia uso de carbamazepina para seu controle. O cuidador principal era, majoritariamente, a mãe, com idade entre 31 a ... / Abstract: Epilepsy is the most common chronic disorders in childhood. Traditionally, medical treatment was concerned with the control of seizures attempting to provide the medication with minimal adverse effects. In recent years studies have shown that the impact of clinical condition and medications extends far beyond the physical domain, potentially causing damage in a cognitive and social and behavioral level. Therefore an assessment of quality of life of children patients and their caregivers was added to clinical practice with the goal of improving the welfare of patients and family. Hence, this study aimed to evaluate the quality of life of children and adolescents with epilepsy attended by public healthcare system in Maringá and identify possible risk and protection factors. Specifically this study focused on the child's clinical and sociodemographic variables, coping strategies and caregiver burden. Fifty two dyads (child/caregiver) attending Neurology clinic and who met the inclusion criteria were selected. Participants responded to the following instruments: Quality of life evaluation scale (AUQEI), Quality of Life of Children with Epilepsy (QVCE 50), Impact of Childhood Illness Scale (ICIS), Ways of Coping Scale (EMEP) and the Zarit Burden Inventory (ZBI).After correcting the tests a descriptive statistical analysis was performed. In a second stage the data received inferential statistical analysis, including analysis of prediction. Participants age range was 4 to 12, 80.8% attended regular school and about half were male, with 0-4 years of education. The most recurrent type of illness condition was generalized epilepsy, while 57.7% of subjects had seizures that started before 4 years of age and 36.5% had daily seizures. ere taking carbamazepine for its control. The main caregiver was mostly the mother, with age range from 31 to 40 years, possessed companion, had 8 years or more of education, acted as caregivers for 8 years or more and ... / Doutor

Made available in DSpace on 2014-06-11T19:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-11-09Bitstream added on 2014-06-13T20:28:36Z : No. of bitstreams: 1 oliveirafilho_n_me_botfm.pdf: 437599 bytes, checksum: 2c2b9a8d5b382a17722a829414485894 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Nos últimos anos o interesse na ocorrência de hiperglicemia no perioperatório de pacientes adultos e pediátricos sem o diagnóstico prévio de diabetes vem aumentando. A maioria dos estudos que demonstram associação entre hiperglicemia e complicações no pós-operatório em pediatria foi realizada em crianças vítimas de trauma ou cirurgia cardíaca. Dados referentes à associação entre hiperglicemia e morbidades em crianças submetidas à ressecção de tumores do sistema nervoso central são escassos na literatura. Avaliar a incidência de hiperglicemia no perioperatório de crianças submetidas à neurocirurgia para ressecção de tumores do sistema nervoso central e correlacionar os níveis de glicemia do perioperatório com a ocorrência de complicações no pós-operatório e identificar os fatores de risco para hiperglicemia perioperatória. Dados de prontuários foram coletados em uma ficha padronizada com informações referentes ao procedimento anestésico-cirúrgico e condições perioperatórias dos pacientes. Hiperglicemia perioperatória foi definida como valores de glicemia ≥150 mg/dL. Análise binária multivariável para identificar fatores de risco de hiperglicemia. Efeitos e diferenças foram considerados estatisticamente significativos se p < 0,05. Foram incluídos 109 pacientes no estudo. A incidência de hiperglicemia foi de 2,9% no pré-operatório, 10,4% no intra-operatório, 42,4% na admissão da UTI e 52,8% considerando a média das glicemias nas primeiras 24h. Níveis mais elevados de glicemia na admissão da UTI (164,2 ± 36,4 e 144,8 ± 42,7 / p=0,004) e nas primeiras 24h (145,3 ± 19,7 e 137,0 ± 25,5 / p= 0,047) foram observadas nos pacientes que cursaram com complicações no pós-operatório. Os pacientes que apresentaram hiperglicemia na admissão da UTI tiveram um maior tempo de internamento na... / In recent years the interest in the occurrence of perioperative hyperglycemia in adult and pediatric patients without prior diagnosis of diabetes is increasing. Most studies that demonstrate an association between hyperglycemia and complications in the postoperative pediatric studies in children were victims of trauma or cardiac surgery. Data regarding the association between hyperglycemia and morbidity in children undergoing resection of tumors of the central nervous system are scarce. Data were collected from medical records in a standardized form with information about the anesthetic and surgical conditions and perioperative patients. Hyperglycemia was defined as blood glucose levels ≥ 150 mg / dl. Binary multivariate analysis to identify risk factors of hyperglycemia. Effects and differences were considered statistically significant if p <0.05. 109 patients were included in the study. The incidence of hyperglycemia was 2.9% preoperative, 10,4% intraoperative, 42,4% at admission to the ICU and 52,8% taking the average of glucose in the first 24 hours. Higher levels of glucose in the ICU admission (164.2 ± 36.4 and 144.8 ± 42.7 / p = 0.004) and in the first 24 hours (145.3 ± 19.7 and 137.0 ± 25.5 / p = 0.047) were observed in patients who presented with postoperative complications. The patients who had hyperglycemia on admission ICU had a longer ICU stay and hospital. Use of intraoperative corticosteroids increased risk of hyperglycemia at admission to the ICU (OR 3.56 / IC(95%) 1,07-11,7/ p= 0,037). Perioperative higher levels of blood glucose are associated with increased postoperative morbidity of pediatric... (Complete abstract click electronic access below)

Thesis (doctoral)--Lund University, 1992. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1992. / Added t.p. with thesis statement inserted.