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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"penicillin -- aphysiological effect."" "subject:"penicillin -- byphysiological effect.""

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Investigations of the interactions of benzylpenicilloic acid with human erythrocytes ; and, RCHDCHDX compounds as stereochemical probes : MINDO/3 and MNDO investigations of conformational preferences in RCHb2sCHb2sX compounds / Investigations of the interactions of benzylpenicilloic acid with human erythrocytes. / RCHDCHDX compounds as stereochemical probes.

Wihebrink, W. Scott 03 June 2011 (has links)
Benzylpenicillin was found to migrate irreversibly into human erythrocytes. No detectable amounts of penicillin bind to the erythrocyte membrane. After migration into the cell, benzylpenicillin is hydrolyzed into benzylpenicilloic acid, which can not migrate out of the cell. DNDS did not affect the appearance of benzylpenicilloic acid in the erythrocyte, therefore showing that: 1) benzylpenicillin does not hydrolyze to benzylpenicilloic acid in the incubation mixture then migrate to the cell, 2) benzylpenicillin migrates into the erythrocyte and is hydrolyzed to benzylpenicilloic acid. Benzylpenicilloic acid does not migrate into erythrocytes.Ball State UniversityMuncie, IN 47306
Penicillin -- Physiological effect.
Stereochemistry.
Ball State University. Thesis (M.S.)

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