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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Structural studies of novel [alpha]-conotoxins /

Dutton, Julie Louise. January 2002 (has links) (PDF)
Thesis (Ph. D.)--University of Queensland, 2003. / Includes bibliographical references.

Synthesis, characterization and application of constrained 7/8 helix

Shi, Feng, 石峰 January 2010 (has links)
In this thesis, constrained 7/8 helix has been developed to enhance the stability of 7/8 helical structure in polar and aqueous solvents for biological application. The synthesis of constrained 7/8 helical peptides has been achieved in two steps. In the first step, a 7/8 helical peptide chain comprising alternating α-L-amino acids and α-D-aminoxy acids was assembled by standard solution phase peptide synthesis protocol. In the second step, a covalent cross-linker as the conformational constraint was incorporated into 7/8 helical peptide at adjacent α-amino acid residues by consecutive intramolecular ring-closing olefin metathesis reaction and catalytic hydrogenation reaction. Conformational properties of constrained 7/8 helical peptides have been explored by applying NMR spectroscopy, theoretical calculation, and circular dichroism spectroscopy to three constrained tetrapeptides 2.2–2.4 and one non-cross-linked reference peptide 2.1. It was discovered that constrained 7/8 helical peptides with a saturated methylene chain as the covalent cross-linker maintained the structural feature of alternating N–O turns and γ-turns, and exhibited increased stability in both organic solvents and aqueous media. No obvious difference was observed for the covalent cross-linker with six, seven, or eight methylene units in improving the stability of 7/8 helix. The constrained 7/8 helix with enhanced structural stability was applied in the design of α-helix mimics. Based on the structure of helix D in the crystal structure of CD81 large extracellular loop, the putative receptor of Hepatitis C Virus envelop 2 (HCV E2) protein, constrained 7/8 helical hexapeptides 4.1 and 4.2 with free N-terminus were designed and synthesized in the form of TFA salt as the candidates of helix D mimics. It was expected that peptides 4.1 and 4.2 could act as the inhibitors of the interaction between helix D and HCV E2 to block HCV entry into cells. Unfortunately, the biological activity test on the ability of peptides 4.1 and 4.2 in HCV inhibition revealed that none of these peptides exhibited detectable inhibitory effect on the entry of HCV into cells and HCV replication at the concentration of 100 μM. / published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

Peptidylamidoglycolate lyase : discovery and characterization

Ping, Dongsheng 05 1900 (has links)
No description available.

Chemical synthesis and biological activity of peptidyl donor substrates for peptidyl transferase / by Julian Francis Bertrand Mercer.

Mercer, Julian Francis Bertrand January 1971 (has links)
xiii, 146 leaves : ill. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 1973

Isolation and characterization of lipid-associated and neurosecretory polypeptides /

Stark, Margareta, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.

Chemical synthesis and biological activity of peptidyl donor substrates for peptidyl transferase /

Mercer, Julian Francis Bertrand. January 1971 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Biochemistry, 1973.

Synthesis and characterization of novel phosphonopeptides /

Allen, William M. January 1997 (has links)
Thesis (M.S.)--Youngstown State University, 1997. / Includes bibliographical references (leaves 36-39).

Bis (2,2,2-trifluoroethoxy) phosphorochloridate : a new method for the synthesis of peptides /

Bowman, Russell A. January 1996 (has links)
Thesis (M.S.)--Youngstown State University, 1996. / Includes bibliographical references (leaf 33).

Mechanism, function, and inhibition of peptide deformylase

Nguyen, Kiet T. January 2005 (has links)
Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xviii, 169 p.; also includes graphics (some col.) Includes bibliographical references (p. 160-169). Available online via OhioLINK's ETD Center

The synthesis of peptides A. [Delta]²-oxazolines with a peptide linkage at the 4- position. B. Glycine peptides by high pressure liquid phase aminolysis /

Gilbert, Walter Wilson, January 1950 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1950. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 189-193).

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