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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The long-term biocompatibility of porous Perfluoropolyether (PFPE) corneal inlays in humans

Prakasam, Ruby Kala, Optometry & Vision Science, Faculty of Science, UNSW January 2009 (has links)
Purpose: To evaluate long-term biocompatibility, optical clarity and the efficacy of Perfluoropolyether (PFPE) polymer as a corneal inlay in humans. Materials and Methods: Corneas of 5 unsighted eyes of 5 patients received inlays: one patient selected as control. All were examined at baseline, immediately post-operative, 7 days and monthly thereafter for 12 months and at 3-monthly intervals for the next 12 months. Clinical evaluation includes detailed slit-lamp biomicroscopy, refraction, keratometry, corneal topography, and other routine ocular examinations. Results: Surgery was uneventful. None of the patients developed corneal oedema or increased vascularisation during study period. All corneas were clear except for minimal haze around the edge of the implant and mild interface reflectivity. Two patients developed epithelial erosion with minimal stromal involvement at 4 and 24 months post surgery resulted in removal of inlay. Inlays remained stable in position in all patients, however clarity has reduced (4% - 26%) gradually with time. We believe mechanical stress from inlay to the surrounding tissue triggered keratocyte activation and extra cellular matrix material deposits around inlay may be responsible for epithelial erosions as well as the reduction in inlay clarity. All test eyes showed acute myopic shift by 8.47D ?? 1.97 (mean ?? SD) following implantation. The epithelial pigment deposits were detected in all test patients following surgery, related to acute corneal curvature changes. The removal data from two patients showed the reversal of the refractive effect to preoperative levels. One patient followed up for an extensive period of 19 months post inlay removal demonstrated stable results. Conclusion: The PFPE inlays have demonstrated excellent biocompatibility within the human corneal tissue for 2 years. The epithelial erosion and inlay clarity reduction were the two major problems encountered in this study. We believe these problems were related to the mechanical stress induced tissue response from inlay. Critical patient selection and the modification of inlay design should improve the success of the procedure. Inlays are effective in altering the refractive status of the eye by altering the anterior corneal curvature. Also, inlay implantation and removal procedures are found to be easy, safe and quick without any complications.
2

Spreading Properties of Monolayer Lubricant Films: Effect of Bonded Molecules

Itoh, Shintaro, Takahashi, Kenichiro, Fukuzawa, Kenji, Amakawa, Hiroaki, Hedong, Zhang 11 1900 (has links)
No description available.
3

Development of perfluoroelastomer-based low-sorption microfluidic devices for drug metabolism and toxicity studies / 薬物代謝・毒性研究のための過フッ素化エラストマー製低収着マイクロ流体デバイスの開発

Wang, Mengyang 23 March 2023 (has links)
京都大学 / 新制・課程博士 / 博士(薬科学) / 甲第24548号 / 薬科博第165号 / 新制||薬科||18(附属図書館) / 京都大学大学院薬学研究科薬科学専攻 / (主査)教授 山下 富義, 教授 髙倉 喜信, 教授 寺田 智祐 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DFAM

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