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Dissertation (DScD) -- Boston University, Henry M. Goldman School of Dental Medicine, 2010 (Department of Periodontology and Oral Biology). / Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced inflammatory response manifested both locally and systemically. The observation that hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory environment indicates that diabetes is an independent risk factor for periodontal disease. Leukocyte pre-activation or priming in diabetes has been demonstrated. Excessive ROS release by leukocytes, upregulation of pro-inflammatory mediators and adhesion molecules are characteristic to T2DM-associated low-grade inflammation. However, the mechanisms by which chronic hyperglycemia leads to leukocyte activation are not fully understood. [TRUNCATED]

Orientador: Luciano Tavares Angelo Cintra / BancaEloi Dezan Junior / Renata Oliveira Samuel / Christine Men Martins / Resumo: O obje tivo deste trabalho foi invest igar a influ ê ncia da extensão da doença periodontal no perfil sanguíneo de ratos Wistar. Foram utilizados 30 ratos divididos em 3 grupos de 10 animais: C - ratos controle ; DP1 - ratos com doença periodontal em 3 molares superiores ; DP2 - ratos com doença per iodontal em 3 molares superiores e 3 inferiores . A doença periodontal foi induzida por meio da confecção de ligadura em torno do colo dentário dos molares selecionados de acordo com cada grupo . Após 30 dias, os animais foram anestesiados e, por meio de uma punção cardíaca, foi coletado 5 ml de sangue para as análises dos parâmetros do hemograma, creatinina, triglicérides e colesterol. Em seguida, os animais foram sacrificados e as maxilas removidas e processadas para análise histopatológica em coloraçã o de H .E . para caracterizar o perfil da doença periodontal em cada animal . Os resultados obtidos a partir do tecido hematológico foram analisados estaticamente por meio dos testes de ANOVA e Tukey, com nível de significância de 5%. Pode - se observar nos grupos DP 1 e DP2 presença de infiltrado inflamatório crônico, perda de inserção conjuntiva, perda de estrutura óssea cortical e alveolar, presença de reabsorções dentárias, presença de b iofilme e sequestro ósseo. Quant o ao perfil sanguíneo, pode - se observar diferen ça estatisticamente significante entre o grupo controle e os grupos DP1 e DP2 em relação à quantidade de leucócitos e linfócitos (p<0,05). Ainda, o grupo DP2 apresentou maior quantidade de leucócito s e neutrófilos em relação ao grupo DP1 e controle (p<0,05 ). Pode - se concluir que a presença da doença periodontal eleva a quantidade de l eucócitos, neutrófilo e linfócitos no sangue de ratos Wistar, e que, a extensão da doença periodontal influencia na quanti dade de leucócitos e neutrófilos. / Abstract: The aim of this study was to evaluate the influence of the periodontal disease extension o n the blood profile of Wistar rats. Thirty rats were divided into 3 groups of 10 animals each : C control rats; DP1 - rats with periodontal disease in 3 upper molars; DP2 - rats with periodontal disease in 3 upper and 3 lower molars. Periodontal disea se was induced by ligature around the tooth according to each group. After 30 days, the animals were killed and 5ml of blood was collected for analyzes of blood cou nt parameters, creatinine, triglycerides and cholesterol. Then the animals were sacrificed and the jaws removed and processed for histopathological analysis to characterize, in H.E. staining, the profile of periodontal disease in each animal. The results f rom the hematologic tissue were analyzed statistically by ANOVA and Tukey test, with 5% significance level. It can be observed in groups DP1 and DP2 presence of chronic inflammatory infiltrates, connective tissue attachment loss and alveolar bone cortical structure loss, presence of resorptions, presence of biofilm and bone sequestration. As for the blood profile, it is can observe a statistically significant difference between the control group and the groups DP1 and DP2 to the amount of leukocytes and lym phocytes (p <0.05). Further, DP2 group had a higher amount of leukocytes and neutrophils compared to DP1 and control group (p <0.05). It can be concluded that the presence of periodontal disease increases the amount of leukocytes, neutrophils, and lymphocy tes in the blood of Wistar rats, and the extent of periodontal disease affects the quantification of leukocytes and neutrophils. / Doutor

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Thesis (M.P.H.M.)--Mahidol University, 1999.

Thesis (M.S.)--University of Michigan, 1968.

Thesis (Ph. D.)--University of Rochester, 1997. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (doctoral)--Hamburger Universität, 1926. / Includes bibliographical references (p. 39-40).

Thesis (Ph. D.)--State University of New York at Buffalo, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.