Class of 2011 Abstract / OBJECTIVES: To establish the risk versus return of pharmacy corporations those are traded publicly on the open market. METHODS: Descriptive retrospective study of financial data obtained through Center of Research in Security Prices (CRSP). Pharmacy corporations were selected by the Standard Industrial Classification Code (SIC code) of 5912. Information that was gathered were monthly security-level stock market prices, value-weighted stock market index, the 30-day return on Treasury bill, SMB, HML, and MOM. Analysis timeframe: 1929-2009. RESULTS: CAPM and Fama-French three factor and four models calculated the data results. CAPM resulted in statistically significant overall beta= 1.04 (p≤0.05). Fama-French three factor model resulted in significant overall beta= 0.87 and overall SMB= 0.79. Fama-French four factor model resulted in significant overall beta= 0.86 and overall SMB= 0.78. CONCLUSION: Over the 80 year time period pharmacy corporations suggested mixed volatility. Risk of investment has never suggested being a viable gain on return of investment versus a 30-day Treasury bill.