Spelling suggestions: "subject:"phosphatidylinositol diphosphates"" "subject:"phosphatidylinositol biphosphates""
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PI(4)-dependent recruitment of clathrin adaptors to the trans-Golgi NetworkWang, Jing. January 2005 (has links) (PDF)
Thesis (Ph. D.) -- University of Texas Southwestern Medical Center at Dallas, 2005. / Vita. Bibliography: 106-116.
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Molecular Mechanisms of Vitamin E Secretion in HepatocytesChung, Stacey Wing-Yee 13 September 2016 (has links)
No description available.
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Structural Determinants of Phosphoinositide Recognition by Grp1 Family Pleckstrin Homology Domains: a DissertationCronin, Thomas Charles 25 October 2005 (has links)
Pleckstrin homology (PH) domains, which play an essential role in membrane trafficking and signal transduction, recognize phosphoinositides with a diverse range of affinities and specificities. The PH domains of the Grp1 family of Arf GTPase exchange factors recognize a select group of phosphoinositides with dramatic differences in specificity, despite 90% sequence identity. The work described in this thesis has focused on the structural basis for these differences. The structure of the Grp1 PH domain revealed structural determinants for phosphoinositide recognition. Through a wide range of crystallographic and biochemical means, the structural basis that accounts for the differential binding affinities amongst the Grp1 family PH domains has also been determined. Furthermore, examination of the structural details of these PH domains bound to different inositol phosphate groups have aided in understanding the structural mechanisms by which all PH domains recognize phosphoinositides.
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