With the advancement of sensor technology and data processing capacities, various types of high volume data are available for process monitoring and prognostics in manufacturing systems. In a broaching process, a multi-toothed broaching tool removes material from the workpiece by sequential engagement and disengagement of multiple cutting edges. The quality of the final part, including the geometric integrity and surface finish, is highly dependent upon the broaching tool condition. Though there has been a considerable amount of research on tool condition monitoring and prognostics for various machining processes, the broaching process is unique in the following aspects: 1) a broaching process involves multiple cutting edges, which jointly contribute to the final part quality; 2) the resharpening and any other process adjustments to the tool can only be performed with the whole broaching tool or at least a whole segment of the tool replaced. The overarching goal of this research is to explore how engineering knowledge can be used to improve process monitoring and prognostics for a complex manufacturing process like broaching. This dissertation addresses the needs for developing new monitoring and prognostics approaches based on various types of data. Specifically, the research effort focuses on 1) the use of in-situ force profile data for real-time process monitoring and fault diagnosis, 2) degradation characterization for broaching processes on an individual component level based on image processing; and 3) system-level degradation modeling and remaining useful life prediction for broaching processes based on multiple images. / Ph. D.