Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2009. / Committee Chair: Lee, Robert; Committee Member: Kemp, Melissa; Committee Member: Prinz, Astrid; Committee Member: Ting, Lena; Committee Member: Wiesenfeld, Kurt.

Thesis (M. Phil.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.

published_or_final_version / abstract / Pathology / Master / Master of Philosophy

Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2009. / In recent years antioxidants present in various beverages have attracted a great deal of research interest due to their potential benefits to human health. Epidemiological evidence shows an indirect relationship between the intake of beverages rich in antioxidants and the reduced incidences of some chronic diseases, certain cancers and coronary heart disease mortality. The study was divided into two phases. The aim of the first phase was to compile a database of antioxidant capacities (Oxygen radical absorbance capacity, Ferric reducing antioxidant potential and Trolox equivalent antioxidant capacity) and contents (polyphenols, flavonols, flavanols, anthocyanins and vitamin C) of selected South African beverages. The second phase of the project included an intervention study to investigate the short term in vivo effects of consumption of an antioxidant-rich beverage, rooibos, on the antioxidant and oxidative stress status of human participants. The parameters that were investigated in human plasma included the total antioxidant capacity (ORAC and FRAP) and content (total polyphenols) as well as the reduced-oxidised glutathione ratios (GSH/GSSG) in erythrocytes. Results from this study were used to compile a database for antioxidant capacities and contents of selected South African beverages. The results showed that, in the case of fruit juices their antioxidant capacity and content covered a wide range. This could be attributed to the juice's differences in fruit composition, e.g. either as a single fruit or as a combination of two or more fruits. In the case of wines, red wines had the highest antioxidant capacity for all the beverages tested and had 22 times higher polyphenols compared to that of white wines. Results also indicated that black tea and coffee had a higher antioxidant capacity and polyphenol content than the local herbal tea, rooibos. The duration of extraction (brewing) of the teas also influenced the antioxidant capacity. Correlations between the three antioxidant capacity assays were very high in the case of wines and teas, but lower in the case of fruit juices. This antioxidant database for South African beverages is useful not only to consumers, but also nutritionist, researchers, dieticians and functional food formulators.

While coffee culture has long since been positively associated with intellectual and working life, the health and safety of its primary stimulant, caffeine, has recently fallen under scrutiny by the FDA. This medical anthropology thesis provides a biocultural synthesis of caffeine culture, health effects, and biological variation in adverse effects related to pharmacodynamics and pharmacokinetics. Supporting evidence for variation in responses to caffeine was found through surveying 100 participants, investigating caffeine consumption levels, perceptions and health beliefs, adverse effects experienced, and medical encounters. Increased rates of adverse effects were found for students, pharmaceutical and over-the-counter drug users, and for participants reporting negative or ambivalent perceptions of caffeine, intolerance, or sensitivity to caffeine. Variation in rates of adverse effects suggests biocultural interactions account not only for patterns in pharmacological data, but are also clinically significant in constructing risk of caffeine intoxication. / Includes bibliography. / Thesis (M.A.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection

Addenda held in pocket pasted onto back end paper. / Bibliography: leaves 137-165. / xvi, 165 leaves : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / This thesis involves the retrospective investigation of the insulin-like growth factors and their binding proteins in the serum of children with chronic renal failure (CRF) and transplantation, before and after treatment with recombinant human growth hormone (rhGH). IGF-IGFBP complexes in pooled serum from prepubertal and pubertal children of both sexes with CRF and renal transplantation, before and after treatment with rhGH, are analysed by fast protein liquid chromatography under neutral conditions. / Thesis (M.D.)--University of Adelaide, Dept. of Paediatrics, 1997?

Thesis (M.S.)--Mississippi State University. College of Veterinary Medicine. / Title from title screen. Includes bibliographical references.

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 200-222).

Indiana University-Purdue University Indianapolis (IUPUI) / Voltage-‐gated sodium channels (VGSCs) are critical for the initiation and propagation of electrical signals in neurons; consequently they are significant regulators of neuronal excitability. They are exquisitely tuned and aberrations in their activity can lead to pathophysiological conditions. This dissertation highlights the roles of two prominent brain isoforms of VGSCs, Nav1.1 and Nav1.6. These isoforms have distinct localization in the brain. Specifically, Nav1.1 is predominantly expressed in the soma and proximal axon initial segment (AIS) of GABAergic neurons, while Nav1.6 is found at the distal AIS and nodes of Ranvier of both GABAergic and excitatory neurons. Several mutations have been identified in Nav1.1 and recently mutations in Nav1.6 have been discovered in patients with distinct epileptic phenotypes that respond poorly to current anti-epileptics. There is a need to better understand mechanistically how mutations in these channel isoforms lead to epilepsy in order to identify more efficacious treatment strategies. Therefore, the aims of this dissertation were to 1) examine the differential biophysical properties of Nav1.1 and Nav1.6, 2) determine the biophysical consequences of epilepsy-­associated mutations in Nav1.1 and Nav1.6 and examine the effects of cannabinoids on wildtype and mutant channel activity and 3) test the effects of selective inhibition of Nav1.1 versus Nav1.6 on epileptiform activity. To address these aims, whole­‐cell electrophysiology and mutlielectrode array recordings were used. The results demonstrate that 1) Nav1.1 and Nav1.6 have important differences in their biophysical properties that may be important in the fine­‐tuning of neuronal excitability, 2) epilepsy-­‐associated mutations in Nav1.1 and Nav1.6 alter several biophysical properties of the channels but have differential effects on resurgent current generation suggesting a divergence in the mechanism by which they induce epileptogenesis and cannabidiol can inhibit aberrant channel activity and reduce neuronal excitability and 3) pharmacological inhibition of Nav1.6, but not Nav1.1, abolishes epileptiform activity. Overall, this dissertation provides insight into the distinct contributions of Nav1.1 and Nav1.6 to physiological and pathophysiological firing activity and their ability to be targeted for therapeutic purposes. This knowledge is critical for understanding the potential role of VGSCs in epilepsy syndromes and identifying possible drug targets for more efficacious treatment strategies.

No description available.