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Thesis (M.S.)--Springfield College, 2003. / Includes bibliographical references.

O objetivo desta pesquisa foi investigar as variáveis cardio-respiratórias (Pa, FC, 'VO IND.2', 'VCO IND.2' e Ve) durante a estimulação elétrica neuromuscular (EENM) do quadríceps em portadores de lesão medular. Participaram da pesquisa dez pacientes (cinco paraplégicos e cinco tetraplégicos) e um sujeito saudável voluntário padrão. O protocolo do teste consistiu em 10 minutos de repouso, 20 minutos de EENM dos quadríceps e 10 minutos de recuperação. O sujeito saudável realizou o mesmo procedimento, entretanto, os movimentos de flexão/extensão dos joelhos foram realizadas de maneira voluntária. Durante a EENM foram constatados baixos valores de 'VO IND.2' e 'VCO IND.2', lenta cinética dos gases e valores alterados de 'P IND.O2' e 'P IND.CO2', em outros casos foi constatada a rápida cinética dos gases. Houve o aumento da Pa sistólica e da FC, entretanto em alguns pacientes observaram-se limitações na resposta da FC. Portanto, os pacientes apresentaram algumas limitações nas respostas cardio-respiratórias, indicando realização de exercício exaustivo, mas apresentaram capacidade de realização de exercício induzido artificialmente, possivelmente devido aos benefícios da EENM / The objective of this research was to evaluate cardio-respiratory responses (heart rate, blood pressure, 'VO IND.2', 'VCO IND.2' e Ve) to neuromuscular electrical stimulation (NMES) of the quadriceps in patients with spinal cord injury. Ten patients (five paraplegics and five tetraplegics) and one healthy subject participated in this study. The protocol of the test consisted of ten minutes of rest, twenty minutes of NMES of the quadriceps and ten minutes of recovery. However, the healthy subject performed the voluntary movement of knee flexion and extension. The findings in this study indicated that patients during NMES demostrated low values of 'VO IND.2' e 'VCO IND.2', slow gas kinetics and altered values of 'P IND.O2' and 'P IND.CO2', on the others cases, the fast kinetics of the gas was verified. Moreover, there were increases in blood pressure and heart rate. Nevertheless, for some patients, heart rate response limitations were observed. Therefore, the patients presented some limitations in the cardio-respiratory responses, indicating performance of exhaustive exercise, but the use of NMES can elicit improvements in exercise tolerance due to its benefits

Made available in DSpace on 2014-06-11T19:23:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-03-03Bitstream added on 2014-06-13T20:30:49Z : No. of bitstreams: 1 machado_lp_me_botfmvz.pdf: 341603 bytes, checksum: b779869a2fd113691f68f4c66bf1832f (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / The objective of this study was to evaluate the oxidative erythrocyte metabolism in equines submitted to exercise on high-speed treadmill and the effect of vitamin E supplementation. Eight adults Arabian horses, males and females, were divided: control group (CG) and group supplemented with vitamin E (EG), (1000 UI/animal/day). All the equines were submitted to exercise with two incremental tests (T1 and T2). Exercise protocol for two tests started with 1.8m/s for 5 min, 4m/s for 3 min, 6m/s for 2 min and right after, periods of 1 min, challenging the equines with increasing speeds until the animals had no condition to keep the exercise on a treadmill inclined at 7%. Between the tests, a training protocol was performed for 20 days. Blood samples were taken before, during, and until 120 hours after exercise to determine erytrogram, erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD), methemoglobin, erythrocyte osmotic fragility (EOF), total plasmatic protein (TPP), seric malondialdehyde (MDA) and vitamin E, seric enzymatic activity of aspartate aminotransferase (AST) and creatine kinase (CK), blood lactate and bloodgas. The results were compared by non-parametric Mann-Whitney and Friedman tests. Although differences were detected in only a few variables, it was possible to see increase in erytrogram and TPP by spleenic contraction and/or decrease of the plasma volume, and increase the erythrocyte volume by swelling. Sport anemia was observed between 24h and 120h after the exercise. The methemoglobin was compatible with the physiological levels and the EOF increased during the exercise in both groups. The MDA elevation confirm the liperoxidation by exercise effect, less intense EG by the supplementation with vitamin E. The exercise also induced increase of AST and CK enzymes, increase of blood lactate and metabolic acidosis.

Orientador : Aguemi Kohayagawa / Banca: Alexandre Secorun Borges / Banca: Maria Adriana Machado Loba e Silva / Abstract: The objective of this study was to evaluate the oxidative erythrocyte metabolism in equines submitted to exercise on high-speed treadmill and the effect of vitamin E supplementation. Eight adults Arabian horses, males and females, were divided: control group (CG) and group supplemented with vitamin E (EG), (1000 UI/animal/day). All the equines were submitted to exercise with two incremental tests (T1 and T2). Exercise protocol for two tests started with 1.8m/s for 5 min, 4m/s for 3 min, 6m/s for 2 min and right after, periods of 1 min, challenging the equines with increasing speeds until the animals had no condition to keep the exercise on a treadmill inclined at 7%. Between the tests, a training protocol was performed for 20 days. Blood samples were taken before, during, and until 120 hours after exercise to determine erytrogram, erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD), methemoglobin, erythrocyte osmotic fragility (EOF), total plasmatic protein (TPP), seric malondialdehyde (MDA) and vitamin E, seric enzymatic activity of aspartate aminotransferase (AST) and creatine kinase (CK), blood lactate and bloodgas. The results were compared by non-parametric Mann-Whitney and Friedman tests. Although differences were detected in only a few variables, it was possible to see increase in erytrogram and TPP by spleenic contraction and/or decrease of the plasma volume, and increase the erythrocyte volume by swelling. Sport anemia was observed between 24h and 120h after the exercise. The methemoglobin was compatible with the physiological levels and the EOF increased during the exercise in both groups. The MDA elevation confirm the liperoxidation by exercise effect, less intense EG by the supplementation with vitamin E. The exercise also induced increase of AST and CK enzymes, increase of blood lactate and metabolic acidosis. / Mestre

O objetivo desta pesquisa foi investigar as variáveis cardio-respiratórias (Pa, FC, 'VO IND.2', 'VCO IND.2' e Ve) durante a estimulação elétrica neuromuscular (EENM) do quadríceps em portadores de lesão medular. Participaram da pesquisa dez pacientes (cinco paraplégicos e cinco tetraplégicos) e um sujeito saudável voluntário padrão. O protocolo do teste consistiu em 10 minutos de repouso, 20 minutos de EENM dos quadríceps e 10 minutos de recuperação. O sujeito saudável realizou o mesmo procedimento, entretanto, os movimentos de flexão/extensão dos joelhos foram realizadas de maneira voluntária. Durante a EENM foram constatados baixos valores de 'VO IND.2' e 'VCO IND.2', lenta cinética dos gases e valores alterados de 'P IND.O2' e 'P IND.CO2', em outros casos foi constatada a rápida cinética dos gases. Houve o aumento da Pa sistólica e da FC, entretanto em alguns pacientes observaram-se limitações na resposta da FC. Portanto, os pacientes apresentaram algumas limitações nas respostas cardio-respiratórias, indicando realização de exercício exaustivo, mas apresentaram capacidade de realização de exercício induzido artificialmente, possivelmente devido aos benefícios da EENM / The objective of this research was to evaluate cardio-respiratory responses (heart rate, blood pressure, 'VO IND.2', 'VCO IND.2' e Ve) to neuromuscular electrical stimulation (NMES) of the quadriceps in patients with spinal cord injury. Ten patients (five paraplegics and five tetraplegics) and one healthy subject participated in this study. The protocol of the test consisted of ten minutes of rest, twenty minutes of NMES of the quadriceps and ten minutes of recovery. However, the healthy subject performed the voluntary movement of knee flexion and extension. The findings in this study indicated that patients during NMES demostrated low values of 'VO IND.2' e 'VCO IND.2', slow gas kinetics and altered values of 'P IND.O2' and 'P IND.CO2', on the others cases, the fast kinetics of the gas was verified. Moreover, there were increases in blood pressure and heart rate. Nevertheless, for some patients, heart rate response limitations were observed. Therefore, the patients presented some limitations in the cardio-respiratory responses, indicating performance of exhaustive exercise, but the use of NMES can elicit improvements in exercise tolerance due to its benefits