Invasive pneumococcal disease (IPD) coursed many deaths worldwide according to World Health Organization. Disease burden of IPD among adults were estimated in western countries. However, relative information is lacking in Asia, which occupies over 60% of global population. The objective of this review is to address the disease burden of IPD among adults in Asian and totally 15 articles was reviewed in this paper. The burden of IPD in Asia among adults is hard to estimate but generally in the high level. The highest case fatality rate was occurred in Taiwan about 30.2% in 2007. The most common antibiotic resistance is penicillin and serotypes among Asian countries is similarly; the most common types are 23F, 3, 6B following by 14, 19F, 4, 18C. The factors affect disease burdens are complexity. In the same time, these reference papers only cover 7 regions or countries among Asian; data from other countries and regions was not enough for analysis. Further study about disease burden of IPD among Asian population in adults is necessarily. / published_or_final_version / Public Health / Master / Master of Public Health