The Politicization of the humanitarian space in armed conflicts takes various forms such as instrumentalization, obstruction, or appropriation, and is correlated to uneven power dynamics between the actors involved. This politicization has adverse effects both in a global context, such as undermining International Humanitarian Law, and in local contexts, in eroding the principles and consequently the lack of access to provide relief to those intended. The ‘war on terror’ in Afghanistan, and the imbalances of postcolonial powers among actors involved show how politicization, especially US instrumentalization, affected the humanitarian space and created a situation of extreme violence against aid workers. On the other hand, the current situation of gendered obstruction under the Taliban regime makes it difficult to assess and deliver the necessary aid to Afghan women. Humanitarian organizations must therefore maintain coordination with each other, be transparent with the actors, and maintain dialogue with all levels of authority in order to alleviate the difficulties generated by politicization in establishing a humanitarian space.