abstract: Background: Postprandial hyperglycemia can increase levels of oxidative stress and is an independent risk factor for complications associated with type 2 diabetes. Purpose: To evaluate the acute effects of a 15-min postmeal walk on glucose control and markers of oxidative stress following a high-carbohydrate meal. Methods: Ten obese subjects (55.0 ± 10.0 yrs) with impaired fasting glucose (107.1 ± 9.0 mg/dL) participated in this repeated measures trial. Subjects arrived at the laboratory following an overnight fast and underwent one of three conditions: 1) Test meal with no walking or fiber (CON), 2) Test meal with 10g fiber and no walking (FIB), 3) Test meal with no fiber followed by a 15-min treadmill walk at preferred walking speed (WALK). Blood samples were taken over four hours and assayed for glucose, insulin, thiobarbituric reactive substances (TBARS), catalase, uric acid, and total antioxidant capacity (TAC). A repeated measures ANOVA was used to compare mean differences for all outcome variables. Results: The 2hr and 4hr incremental area under the curve (iAUC) for glucose was lower in both FIB (2hr: -93.59 mmol&#8729;120 min&#8729;L-1, p = 0.006; 4hr: -92.59 mmol&#8729;240 min&#8729;L-1; p = 0.041) and WALK (2hr: -77.21 mmol&#8729;120 min&#8729;L-1, p = 0.002; 4hr: -102.94 mmol&#8729;240 min&#8729;L-1; p = 0.005) conditions respectively, compared with CON. There were no differences in 2hr or 4hr iAUC for glucose between FIB and WALK (2hr: p = 0.493; 4hr: p = 0.783). The 2hr iAUC for insulin was significantly lower in both FIB (-37.15 &#956;U &#8729;h/mL; p = 0.021) and WALK (-66.35 &#956;U &#8729;h/mL; p < 0.001) conditions, compared with CON, and was significantly lower in the WALK (-29.2 &#956;U &#8729;h/mL; p = 0.049) condition, compared with FIB. The 4hr iAUC for insulin in the WALK condition was significantly lower than both CON (-104.51 &#956;U &#8729;h/mL; p = 0.001) and FIB (-77.12 &#956;U &#8729;h/mL; p = 0.006) conditions. Markers of oxidative stress were not significantly different between conditions. Conclusion: A moderate 15-minute postmeal walk is an effective strategy to reduce postprandial hyperglycemia. However, it is unclear if this attenuation could lead to improvements in postprandial oxidative stress. / Dissertation/Thesis / Doctoral Dissertation Physical Activity, Nutrition and Wellness 2015