Liu Hua. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (leaves 139-143). / Abstracts in English and Chinese. / Table of Contents --- p.I / Acknowledgement --- p.VII / Abstract --- p.VIII / Abstract (Chinese) --- p.X / List of Tables --- p.XV / List of Figures --- p.XXIV / List Symbols and Abbreviations / Chapter Chapter One --- Introduction / Chapter 1.1. --- Rationale of study --- p.2 / Chapter 1.2. --- Drug Delivery to the lungs --- p.5 / Chapter 1.3. --- Particle transport and deposition mechanisms --- p.8 / Chapter 1.4. --- Factors affecting particulate interactions --- p.9 / Chapter 1.4.1. --- Particle size --- p.9 / Chapter 1.4.2. --- Particle shape --- p.10 / Chapter 1.4.3. --- Surface texture --- p.10 / Chapter 1.4.4. --- Surface energy --- p.11 / Chapter 1.4.5. --- Contact area --- p.12 / Chapter 1.4.6. --- Relative humidity --- p.12 / Chapter 1.4.7. --- Electrical properties --- p.13 / Chapter 1.5. --- Fine powder production technologies applicable to dry powder inhalation formulations --- p.13 / Chapter 1.5.1. --- Batch crystallization and micronization --- p.14 / Chapter 1.5.2. --- Spray drying --- p.15 / Chapter 1.5.3. --- Supercritical fluid crystallization --- p.17 / Chapter 1.6. --- Physical characterization of aerosol powders --- p.18 / Chapter 1.6.1. --- Microscopy and particle size analysis --- p.19 / Chapter 1.6.2. --- Powder X-ray diffractometry --- p.19 / Chapter 1.6.3. --- Thermal analysis --- p.20 / Chapter 1.6.4. --- In-vitro deposition assessment --- p.20 / Chapter 1.6.5. --- Surface energy measurement by inverse gas chromatography (IGC) --- p.21 / Chapter 1.7. --- Scope of study --- p.22 / Chapter Chapter Two --- Materials and Methods / Chapter 2.1. --- Materials --- p.25 / Chapter 2.2. --- Equipment --- p.25 / Chapter 2.3. --- Methods --- p.27 / Chapter 2.3.1. --- Determination of aqueous solubility of salbutamol sulphate in water --- p.27 / Chapter 2.3.2. --- Preparation of spray-dried salbutamol sulphate powders under different operating conditions --- p.27 / Chapter 2.3.3. --- Preparation of spray-dried salbutamol sulphate powders at various lecithin concentrations --- p.30 / Chapter 2.3.4. --- Preparation of spray-dried salbutamol sulphate powders at various oleic acid concentrations --- p.32 / Chapter 2.3.5. --- Physical characterization of spray-dried salbutamol sulphate powders --- p.34 / Chapter 2.3.5.1. --- Scanning electron microscopy --- p.34 / Chapter 2.3.5.2. --- Specific surface area determination --- p.34 / Chapter 2.3.5.3. --- Particle size distribution measurements --- p.35 / Chapter 2.3.5.4. --- Water content determination --- p.36 / Chapter 2.3.5.5. --- Isothermal water vapour sorption studies --- p.37 / Chapter 2.3.5.6. --- Powder X-ray diffraction --- p.37 / Chapter 2.3.5.7. --- Thermal analysis --- p.38 / Chapter 2.3.5.8. --- Surface energy measurement by inverse gas chromatography --- p.39 / Chapter 2.3.5.8.1. --- Calculation of surface thermodynamic parameters --- p.40 / Chapter 2.3.5.8.1.1. --- Standard Free Energy of Adsorption and Related Thermodynamic Parameters --- p.40 / Chapter 2.3.5.8.1.2. --- Dispersive Component of Surface Free Energy and Related Thermodynamic Parameters --- p.41 / Chapter 2.3.5.8.1.3. --- Specific Interactions and Associated Acid-Base Properties --- p.42 / Chapter 2.3.5.9. --- In-vitro deposition measurement by multi-stage liquid impinger --- p.43 / Chapter Chapter Three --- Results and discussion / Chapter 3.1. --- Influence of spray drying operating parameters --- p.46 / Chapter 3.1.1. --- Drying temperature --- p.46 / Chapter 3.1.1.1. --- "Particle size, particle morphology, and specific surface area" --- p.46 / Chapter 3.1.1.2. --- "Crystallinity, moisture sorption and thermal behaviour" --- p.53 / Chapter 3.1.1.3. --- Surface thermodynamic properties --- p.60 / Chapter 3.1.1.4. --- Aerodynamic properties and in-vitro deposition --- p.64 / Chapter 3.1.2. --- Feed solution concentration --- p.67 / Chapter 3.1.2.1. --- "Particle size, particle morphology and specific surface area" --- p.69 / Chapter 3.1.2.2. --- "Crystallinity, moisture sorption and thermal behaviour" --- p.69 / Chapter 3.1.2.3. --- Surfacethermodynamicproperties --- p.70 / Chapter 3.1.2.4. --- Aerodynamic properties and in-vitro deposition --- p.70 / Chapter 3.1.3. --- Feed speed --- p.72 / Chapter 3.1.3.1. --- "Particle size, particle morphology, and specific surface area" --- p.72 / Chapter 3.1.3.2. --- "Crystallinity, moisture sorption and thermal behaviour" --- p.73 / Chapter 3.1.3.3. --- Surfacethermodynamicproperties --- p.73 / Chapter 3.1.3.4. --- Aerodynamic properties and in-vitro deposition --- p.73 / Chapter 3.2. --- Influence of formulation additives --- p.78 / Chapter 3.2.1. --- Influence of lecithin as additive --- p.78 / Chapter 3.2.1.1. --- "Particle morphology, particle size and specific surface area" --- p.79 / Chapter 3.2.1.2. --- "Crystallinity, moisture sorption and thermal behaviour" --- p.84 / Chapter 3.2.1.3. --- Surfacethermodynamicproperties --- p.90 / Chapter 3.2.1.4. --- Aerodynamic properties and in-vitro deposition --- p.94 / Chapter 3.2.2. --- Influence of oleic acid as additive --- p.101 / Chapter 3.2.2.1. --- "Particle morphology, particle size and specific surface area" --- p.101 / Chapter 3.2.2.2. --- "Crystallinity, moisture sorption and thermal behaviour" --- p.106 / Chapter 3.2.2.3. --- Surfacethermodynamicproperties --- p.123 / Chapter 3.2.2.4. --- Aerodynamic properties and in-vitro deposition --- p.127 / Chapter Chapter Four --- Conclusion and Future Work / Chapter 4.1. --- Conclusion --- p.134 / Chapter 4.1.1. --- Influence of spray drying operating parameters --- p.134 / Chapter 4.1.2. --- Influence of formulation additives --- p.135 / Chapter 4.2. --- Future Work --- p.137 / References --- p.139

Tong Hoi Yee. / "July, 2003." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (p. 237-253). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.