It is the goal of this project to investigate the energy conservation measures which can be adapted in an electronic manufacturing plant HVAC system. Computer simulation has been proceeded using Power DOE as a tool in evaluating the power consumption of HVAC, lighting and auxiliary systems, validated by full-scale experimental field measurements so that optimal operation strategies can be established for energy savings. Experimental result indicated that the HAVC system consumes 34% of that of the whole plant with 19% consumed by chillers. Comparatively, the simulation result indicated that HVAC system consumes 36% of the total which confirms the potential for energy savings. It is concluded and recommended that the DHC , or District Heating and Cooling system can be adapted in this situation which coupled with the multiple-chiller controls with variable water volume (VWV) pumping for optimal operation through the direct digital controls.