Multiple theoretical frameworks posit that interactions between the autonomic nervous system and higher-order neural networks are crucial for cognitive regulation. However, few studies have directly examined whether autonomic physiology influences brain activity during cognitive tasks, and even fewer of those studies have examined both autonomic branches when doing so. Measures of selective attention derived from event-related brain potentials (ERPs) are particularly well-suited for addressing this question, given that ERP selective attention tasks are designed to control for the influences of psychomotor processes and arousal and are predictive of higher-order cognitive function in children and adults. Such research is particularly promising for understanding how early adversity impacts neurocognitive development in children, given that stress experienced early in life impacts both autonomic function and selective attention. Here, a broad literature review is presented, integrating findings across studies of autonomic physiology, cognition, and brain activity in children and adults (Chapter 1). Then, two experiments are described where cardiac measures of parasympathetic and sympathetic activity were recorded concurrently with ERPs during an auditory selective task in a sample of adults (Chapter 2) and in a sample of preschool-aged children (Chapter 3). Results from both experiments demonstrate a key role for the sympathetic nervous system in selective attention for adults and children, such that greater sympathetic activity is associated with larger effects of selective attention on ERPs. These findings are then reviewed with suggestions for how existing models of neurovisceral integration might be updated to better emphasize the role of sympathetic nervous system activity in neurocognitive processes, emphasizing measures of threat-related and reward-related arousal, as represented by galvanic skin response and pre-ejection period, respectively (Chapter 4). Future directions are also discussed, including recommendations for future studies of neurovisceral integration to examine associations between physiology, behavior, and brain activity at the single-trial level, to incorporate participants from more diverse backgrounds of life experience, and to examine the plasticity of autonomic mechanisms implicated in neurocognitive function.

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The autonomic flexibility model has proven to be a useful theoretical tool relating reductions in physiological variability found to accompany anxiety and concomitant reductions in behavioral (e.g., cognitive and emotional) flexibility. The present study aimed to extend the autonomic flexibility model through the inclusion of individual differences in the sensitivity of the independent motivational systems presumed to underlie anxiety and impulsivity, namely the behavioral inhibition and activation systems (BIS/BAS; Gray, 1994). Contrary to the predicted inverse relationship between BIS sensitivity and measures of physiological variability, findings suggest BAS sensitivity is associated with increased trait-like vagally mediated heart rate variability across diverse tasks as well as greater flexibility in responding within tasks. Numerous BIS*BAS interactions emerged as significant predictors of trait reactivity. Results are discussed in terms of the interface between (1) mesolimbic dopaminergic projections to the nucleus accumbens and (2) the network of central nervous system structures believed to play a large role in controlling peripheral physiology. / Ph. D.

The Behavioral Activation System (BAS) has been described as playing a central role in approach motivation and reward sensitivity (Gray, 1970). Self-report measures of BAS (e.g., Carver & White, 1994) have been used to index BAS activity, with higher scores interpreted as indicating greater BAS activity (e.g., Hundt et al., 2008). However, Beauchaine and colleagues (e.g., Brenner, Beauchaine, & Sylvers, 2005) have challenged this view, noting psychophysiological and neuroimaging evidence showing that externalizing behaviors are associated with reduced BAS functioning. Furthermore, global self-reported BAS scores are often used to index approach behavior, despite evidence that two main BAS traits, impulsivity and reward reactivity, are psychometrically distinct (Smillie et al., 2006). The present study tested a measurement model of these proposed components of BAS, as well as relationships between self-report and psychophysiological BAS indices. A large undergraduate student sample completed self-report indices (N=599) and a smaller subsample also completed psychophysiological (N=18) indices of BAS-related constructs. As hypothesized, a two-factor model with impulsivity and reward reactivity as separate, correlated constructs demonstrated better model fit than a one-factor alternative model. Associations between psychophysiological indices of BAS and indices of reward reactivity and impulsivity were mixed. Implications regarding future measurement of BAS and autonomic response to reward are discussed. / Master of Science

Gross' emotion regulation model, Porges' polyvagal theory, and other existing research suggest that regulation of emotions, tactics used to handle conflict, and certain physiological processes that occur within the autonomic nervous system (ANS) in response to stress are significantly related, especially in relational contexts. However, despite their pervasiveness and negative impacts, there is a noticeable lack of research on predictors of violent, aggressive, or abusive conflict tactics in couples. In the current study, the predictive role of emotion regulation in relation to conflict tactics was examined, in addition to the role of respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) as mediators for these variables. Thirty-eight participants (19 couples) completed self-report measures of emotion regulation and conflict tactics, and RSA and PEP were measured during a three-minute baseline and 20-minute conflict discussion. Results showed no significant relationships between emotion regulation and conflict tactics, and no significant relationships between these variables and RSA or PEP were found. These findings may suggest that other variables aside from measures of ANS activity better explain the relationship between emotional and behavioral regulation skills, though additional research is necessary to confirm these findings. Clinical implications of this research point to the exploration of other contributors to violence and aggression aside from poor emotion regulation as it was measured in this study. Future research may benefit from investigating the impact of other variables such as sleep and exercise on ANS reactivity in relation to the use of maladaptive conflict tactics in married couples.