BACKGROUND: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality, affecting 2-8% of pregnancies worldwide. It is estimated that 76,000 women and 500,000 babies die from this disease each year globally. Preeclampsia is characterized as hypertension associated with the onset of proteinuria, maternal organ dysfunction or uteroplacental dysfunction occurring at or after 20 weeks of gestation. In addition to its effects on pregnancy, preeclampsia may also have long-term adverse effects on women who experience the disorder and their children later on in life. Currently, the only cure for preeclampsia is delivery, which is often associated with preterm birth, increasing the risk of neonatal death. Daily low-dose aspirin (81mg) has been shown to have a preventive effect on preeclampsia in women at high risk of developing the disorder. OBJECTIVE: To analyze patient data collected at Boston Medical Center to determine the effects of prescribed low dose prenatal aspirin (81 mg) on pregnancy outcomes. METHODS: There were 2648 obstetric deliveries at Boston Medical Center in the two-year span of 2017-2018. Using R, statistical analyses were performed to determine the difference in birth outcomes between the prenatal aspirin prescribed group and the non-aspirin prescribed group as well as the effect of prenatal aspirin on pregnancy outcomes. Logarithmic and linear models as well as basic statistical methods were employed for the analyses. RESULTS: The prenatal aspirin prescribed population had higher major and moderate risk factors as well as worse birth outcomes, Apgar scores and birthweight as compared with the non-prescribed population. However, prenatal aspirin may reduce the adverse effects of both major and moderate risk factors on birth outcomes. CONCLUSIONS: Prenatal aspirin may have beneficial effects on birth outcomes, and the pregnant population at Boston Medical Center may benefit from taking low-dose aspirin. This study was carried out retrospectively with a cohort that was not randomized, so this conclusion needs to be verified by future studies.