This diploma thesis deals with pressure losses in heating systems. The diploma thesis is divided into three sections. The first part is theoretical and deals with the occurrence of pressure losses. It discusses the properties of the fluid that affect pressure losses. It also deals with hydrodynamic phenomena, flow distribution, pressure loss distribution and its calculations. The aim of the second part, which is practical, was to create a heating project for a selected object. The object is a two-floor kindergarten building located in Velké Němčice. For this project, two heating variants were created. For the first variant, radiators and heating benches were designed and for the second variant, underfloor heating was installed in the building. The goal was to use a source which will gain heat mainly from renewable sources, so the air / water heat pump was chosen as the source of heat production. The project ends with a technical report. The third part of the thesis is dedicated to an experiment which purpose was to find out how the pressure losses of the connecting pieces are reacting to the change with the change of the heating water conditions (flow, temperature). Alongside, two pipes were created which differed in the type of connecting pieces so it allowed to compare how their pressure losses differ. Both pipes were connected by radial pressing, but the fittings differed in the quality of the brass, and therefore in the construction. Also, part of the experimental section of the diploma thesis is a description of the course of radial pressing of fittings from the Herz company.