This paper is based on expertise structure and knowledge management (KM) perspective to develop an empirical ¡§Input-Process-Outcome¡¨ model to examine the relationship among expertise complement, expertise deployment, expertise location, expertise integration, problem-solving competency and project performance in the context of information system development (ISD) teams. We adopted the survey method and focused on the members in ISD teams to collect research data. PLS analysis was employed to examine the research model. A total of 76 ISD teams, including 337 members, confirmed our model. Results revealed that (1) expertise complement and expertise deployment are two antecedents that positively affect expertise integration and problem-solving competency; (2) expertise location is found to have a main impact on expertise deployment and expertise integration; (3) expertise integration and problem-solving competency serving as mediators are found to have a positive impact on project performance. This study offers a perspective for conducting the research and practice, as well as achieving a better insight into the fields of expertise composition structure, KM, and ISD.