The slowdown of Moore's Law opened a new era of computer research and development. Researchers started exploring alternatives to the traditional CPU design. A constant increase in consumer demands led to the development of CMPs, GPUs, and FPGAs. Recent research proposed the development of heterogeneous-ISA systems and implemented the necessary systems software to make such systems functional. Evaluations have shown that heterogeneous-ISA systems can offer better throughput and energy efficiency than homogeneous-ISA systems. Due to their low cost, ARM servers are now being adopted in data centers (e.g., AWS Graviton). While prior work provided the infrastructure necessary to run applications on heterogeneous-ISA systems, their dependency on a specialized kernel and a custom compiler increases deployment and maintenance costs. This thesis presents HetMigrate, a framework to live-migrate Linux processes over heterogeneous-ISA systems. HetMigrate integrates with CRIU, a Linux mechanism for process migration, and runs on stock Linux operating systems which improves its deployability. Furthermore, HetMigrate transforms the process's state externally without instrumenting state transformation code into the process binaries which has security benefits and also improves deployability. Our evaluations on Redis server and NAS Parallel Benchmarks show that HetMigrate takes an average of 720ms to fully migrate a process across ISAs while maintaining its state. Moreover, live-migrating with HetMigrate reduces the attack surface of a process by up to 72.8% compared to prior work. Additionally, HetMigrate is easier to deploy in real-world systems compared to prior work. To prove the deployability we ran HetMigrate on a variety of environments like cloud instances (e.g. Cloud Lab), local setups virtualized with QEMU/KVM, and a server-embedded board pair. Similar to works in the past, we also evaluated the energy and throughput benefits that heterogeneous-ISA systems can offer by connecting a Xeon server to three embedded boards over the network. We observed that selectively offloading compute-intensive workloads to embedded boards can increase energy efficiency by up to 39% and throughput by up to 52% while increasing the cost by just 10%. / Master of Science / In 1965 Gordon Moore predicted that the number of transistors in a chip will double every two years. Commonly referred to as "Moore's Law" it no longer holds true and its slowdown opened a new era of computer research and development. Researchers started exploring alternatives to traditional computer designs. A constant increase in consumer demands led to the development of portable, faster, and cheaper computers. Some researchers also started exploring the performance and energy benefits of computing systems that had heterogeneous architecture. Instruction Set Architecture (ISA) is the interface between software and hardware. Recent research proposed the development of systems that had cores of different ISA and implemented the necessary software to make such systems functional. Evaluations have shown that heterogeneous-ISA systems can offer better throughput and energy efficiency than traditional systems. To decrease their cost-to-performance ratio data centers have started adopting servers belonging to diverse architectures making them heterogeneous in nature. While prior work provided the infrastructure necessary to run applications on heterogeneous systems, it suffered from deployability limitations. This thesis presents HetMigrate, a framework that enables stateful program migration in heterogeneous systems. HetMigrate runs on stock open-source operating systems which makes it easy to deploy. Our evaluations show that while HetMigrate performs two orders of magnitude slower than prior work, it can be deployed with ease.