The domestic construction project contracts have made a great development to large-scale lump sum turnkey project, which includes engineering, procurement and construction. The turnkey contractors are responsible for the interface integration among various projects to reduce the delays caused by poor interface coordination, and to shorten the project schedule, moreover to ensure project quality. However, there are huge discrepancies between lump sum turnkey construction projects and general construction projects. Lump sum turnkey projects require a wider field of engineering project management covering the project planning and project control of engineering design, procurement and site construction. So, it is important to do further research in this area. The main purpose of this study is to develop a complete project management framework for large-scale lump sum turnkey projects from the standpoint of a project owner. A real case of the LNG (Liquified Natural Gas) receiving terminal project at Taichung Harbor was used to verify the feasibility of the proposed framework. This study is based on literature review, interview and case study of a large-scale lump sum turnkey project. The engineering project management system of a large-scale construction contractor was studied. The interviewees included top management personnel, information system personnel, and project management system users of the best practice company. The results of this study serve as guidelines of large-scale lump sum turnkey construction project management for project owners. It¡¦s also beneficial for small and median sized contractors to learn from best practice experiences.