There is a need to increase awareness among African American men regarding their potential risk of prostate cancer and inform them of screening and treatment options, given the health disparities that affect their group. To do so, an innovative e health video was developed, using an animated avatar video to educate African American males about prostate cancer and potential screening methods in a way that is culturally appropriate. Effectiveness of this e-health intervention was tested on a sample of 41 African American males. Efficacy was measured using a repeated measures design that used pre- and post-measures of four target behaviors regarding prostate cancer screening. These four target behaviors include: (1) getting an annual physical exam, (2) discussing the possibility of getting a digital rectal exam to screen for prostate cancer with a doctor, (3) discussing the possibility of getting a PSA exam to screen for prostate cancer with a doctor, and (4) spreading awareness about prostate cancer among other African American men. The stage of change, which is a theoretical framework adapted from Prochaska and DiClemente (1983), measures changes in human behavior from precontemplation and contemplation on the low end to action and maintenance on the high end. Self-efficacy was also measured before and after the intervention for each of the four target behaviors. Paired t-tests show that the stage of change for the third and fourth target behaviors and self-efficacy for the second, third, and fourth target behaviors were significantly increased by the e-health intervention, indicating that the intervention was successful. Additionally, participant ratings about the intervention were largely positive. In effect, this study finds that the e-health intervention developed in this study not only works, but is an affordable, scalable, and practical tool that can educate African American males about prostate cancer screening practices.