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Chemical shift tools in peptide folding and miniature protein design /Neidigh, Jonathan Wesley, January 1999 (has links)
Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (p. 190-204).
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Exploring the structurial diversity and engineering potential of thermophilic periplasmic binding proteinsCuneo, Matthew Joseph, January 2007 (has links)
Thesis (Ph. D.)--Duke University, 2007. / Includes bibliographical references.
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Investigation on the stability of freeze dried horseradish peroxidase and immunoglobulin G /Dai, Jialu. January 2010 (has links)
Includes bibliographical references (p. 91-95).
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Delivery of thermostabilized chondroitinase ABC enhances axonal sprouting and functional recovery after spinal cord injuryLee, Hyun-Jung. January 2009 (has links)
Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010. / Committee Chair: Ravi V. Bellamkonda; Committee Member: Andreas Bommarius; Committee Member: Andrés J. García; Committee Member: Niren Murthy; Committee Member: Robert J. McKeon. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Computational simulation of biological systems studies on protein folding and protein structure prediction /Zhang, Wei. January 2005 (has links)
Thesis (Ph. D.)--University of Delaware, 2005. / Principal faculty advisor: Yong Duan, Dept. of Chemistry & Biochemistry. Includes bibliographical references.
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Engineering ligand-receptor pairs for small molecule control of transcriptionSchwimmer, Lauren J. January 2005 (has links)
Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006. / Doyle, Donald, Committee Chair ; Radhakrishna, Harish, Committee Member ; Bommarius, Andreas, Committee Member ; Orville, Allen, Committee Member ; Seley, Katherine, Committee Member.
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Analysis of the binding mechanisms and cellular targets of peptide inhibitors that block site-specific recombination in vitro /Kepple, Kevin V. January 2006 (has links)
Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2006. / Vita. Includes bibliographical references (leaves 162-174).
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The engineering of de novo pathways for oxidative protein folding in Escherichia coliMasip, Lluis, January 1900 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.
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Engineering an Alkane-Hydroxylating Bacterial Monooxygenase: A Tale of Two ChemistriesNanda, Arjun 01 January 2017 (has links)
Toluene / o-xylene monooxyenase (ToMO) from Pseudomonas sp. OX1 is a multimeric metalloenzyme enzyme that efficiently catalyzes the hydroxylation of aromatic hydrocarbons with high specificity. Though included in a larger group of conserved bacterial multicomponent monooxygenases (BMMs) studied as potential biocatalysts for industrial hydrocarbon chemistry, the substrate specificity and oxygenated intermediates of ToMO differ greatly from its well-characterized, alkane-hydroxylating analog sMMO. Despite a shared global topology and near identical active sites, sMMO can cleave inert C-H bonds in alkanes while ToMO cannot - two seemingly similar structures give rise to vastly different chemistries. This work seeks to determine a structural basis for this difference by mutational analysis of residues thought to conformationally constrain the active site in ToMO, with the goal of replicating the terminal alkane hydroxylating activity of sMMO.
To this end, a library of potential alkane-hydroxylating mutants was generated and kinetically characterized, revealing a range of novel behaviors including significant reaction rate enhancements. In combination with low-level computational modeling to quantify the bulk and local rigidity of both sMMOH and ToMOH, we propose a broader strategy for BMM scaffolds to achieve a variety of specific and efficient hydrocarbon chemistries.
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Directed evolution of B-xylanase from Thermomyces lanugtnosusStephens, Dawn Elizabeth January 2000 (has links)
Submitted in partial fulfillment of the requirements for the Degree of Master of Technology: Biotechnology, Durban Institute of Technology, 2000 / M
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