Global ETD Search

111	Oligomerization of the lysr-type transcriptional regulators in Escherichia Coli Knapp, Gwendowlyn Sue 15 May 2009 (has links) Protein-protein interactions regulate and drive biological processes and understanding the assembly of these interactions is important. The LysR-Type Transcriptional Regulators (LTTRs) are a large family of transcriptional regulators found in prokaryotes. I have used the LTTRs as a model for protein specificity. In order to understand a residue’s contribution to oligomerization, alanine-scanning mutagenesis was used to probe the contribution of residues identified from in silico analysis of two proteins: OxyR and CynR. The contribution of the residues to oligomerization was characterized using lcI repressor fusions. In OxyR, seven residues were identified as hot spots. Moreover, these hot spots are not especially conserved. The interaction surface of OxyR was mapped onto a multiple sequence alignment of the LTTR family. This mapping identified putative contacts in the CynR regulatory domain dimer interface. Combined with the in vivo testing, three residues were identified as hot spots. The residues identified in OxyR and CynR do not overlap. To investigate the assembly of the LTTRs I used a negative-dominance assay with lcI repressor fusions. Taken together, I show that the LTTRs in E. coli K-12 are mostly specific in their interactions. protein-protein interactions LysR-Type Transcriptional Regulators
112	Determination of the three-dimensional structure of selenocysteine insertion sequence and analysis of the RNA-binding properties of the Ebola virus transcriptional activator VP30 / Beribisky, Alexander. January 2008 (has links) Thesis (M.Sc.)--York University, 2008. Graduate Programme in Chemistry. / Typescript. Includes bibliographical references (leaves 82-88). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR38748
113	The statistical mechanics of free and protein-bound DNA by Monte Carlo simulation Czapla, Luke. January 2009 (has links) Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Chemistry and Chemical Biology." Includes bibliographical references (p. 119-125).
114	Characterization of QKI RNA binding function / Loushin Newman, Carrie Lee, January 2000 (has links) Thesis (Ph. D.)--University of Texas at Austin, 2000. / Vita. Includes bibliographical references (leaves 138-149). Available also in a digital version from Dissertation Abstracts.
115	Two wavelength high intensity irradiation for effective crosslinking of DNA to protein Guler, Emine. January 2004 (has links) Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: protein-DNA crosslinking; UV laser. Includes bibliographical references (p. 73-77).
116	Peptide-based polyintercalators as sequence-specific DNA binding agents / Guelev, Vladimir Metodiev, January 2001 (has links) Thesis (Ph. D.)--University of Texas at Austin, 2001. / Vita. Includes bibliographical references (leaves 190-204). Available also in a digital version from Dissertation Abstracts.
117	Identification and characterization of PIN1 binding partners Cheng, Chi-wai., 鄭智威. January 2010 (has links) published_or_final_version / Medicine / Doctoral / Doctor of Philosophy Peptidylprolyl isomerase. Protein-protein interactions. Carcinogenesis.
118	The tango between two proteins: insight into the nickel delivery process exerted by HypA and HypB during [Ni, Fe]-hydrogenase maturation in helicobacter pylori Xia, Wei, 夏炜 January 2011 (has links) published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy Helicobacter pylori - Molecular aspects. Protein-protein interactions.
119	Probing specificity of RNA : ribonucleoprotein interactions through in vitro selection Cox, James Colin, 1974- 28 August 2008 (has links) Not available / text Nucleoproteins RNA-protein interactions Protein engineering
120	RNA/protein interactions during group II intron splicing and toward group II intron targeting in mammalian cells Cui, Xiaoxia 28 August 2008 (has links) Not available / text Mammals--Cytology RNA-protein interactions RNA splicing

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