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`In vitro` mucopolysaccharide metabolism of epithelial tissue cells / Ole Walter WiebkinWiebkin, Ole Walter January 1983 (has links)
Offprints of the author's articles inserted / Bibliography: leaves 230-265 / List of the author's publications: leaves 266-263 [i.e. 267] / 263 [i.e. 268] leaves : ill. (1 col.) ; 31 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Dental Science, 1984
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Allergen-induced asthma is decreased in decorin-deficient miceMarchica, Cinzia Loreta, 1984- January 2008 (has links)
Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis. We questioned whether decorin deficiency would alter allergen-induced asthma in a mouse model. Decorin-/- and decorin+/+ mice (C57Bl/6) were sensitized and challenged with ovalbumin. Control animals received saline. Responsiveness was assessed at baseline and after delivery of increasing concentrations of methacholine. Histological analyses were also performed. Decorin deficiency resulted in more modest hyperresponsiveness. Respiratory resistance and elastance along with tissue damping and tissue elastance, were increased in ovalbumin decorin +/+ and decorin-/-, but more so in decorin+/+ . Airway resistance was increased in ovalbumin decorin+/+ only. Inflammation and collagen staining within the airway wall, were increased in ovalbumin decorin+/+ mice only; whereas biglycan was significantly increased in ovalbumin decorin-/- mice only. These results reflect the role of decorin in the development of allergen-induced asthma.
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Allergen-induced asthma is decreased in decorin-deficient miceMarchica, Cinzia Loreta, 1984- January 2008 (has links)
No description available.
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