Despite the important values forests play in the tropics, sustainable forest management still remains a challenge as manifested through continued forest loss. The objective of this study was to provide information on the dynamics of forest cover and their drivers vital for enhancing sustainable forest management in the Lake Victoria crescent, Uganda. Several methodologies including remote sensing and Geographic Information Systems techniques, analysis of landscape patterns and various social science techniques were integrated in working towards the stated goal. Results showed that the Lake Victoria crescent, Uganda covering an area of about 1,509,228 ha, experienced a decline in forest cover from 9.0% in 1989 to 4.4% in 2009. This was in comparison with non-forest cover which increased from 58.7% in 1989 to 63.5% in 2009 while open water coverage generally remained unchanged averaging 32.3% from 1989 to 2009. Mean annual deforestation rate from 1989 to 2009 decreased with a weighted mean rate of 2.56%. Both deforestation and afforestation declined between 1989 and 2009 although deforestation still exceeded afforestation. In addition to deforestation, the Lake Victoria crescent also experienced forest fragmentation from 1989 to 2009. Forests greater than 100 ha in size were the most vulnerable to forest fragmentation yet they still constituted a big proportion of forest cover in 2009. Deforestation was a consequence of proximate causes which were triggered by a number of underlying drivers acting singly or in combination, with underlying drivers being more influential. In a bid to promote sustainable forest management, there is a need to continue with efforts to curb deforestation and forest fragmentation, especially amongst forests greater than 100 ha. This could be achieved through empowerment of local communities to take a core role in sustainable management of forest resources. / Ph. D.