Since adrenocorticotrophic hormone (ACTH) and cortisone have become of importance for therapeutic use, the factors which regulate the secretion of ACTH have been extensively studied (1). Three views have been put forward concerning this regulation; a) that ACTH secretion is controlled by the systemic blood level of adrenaline; b) that its secretion is controlled and regulated by the systemic blood level of adrenal cortical hormones and; c) it may be controlled by the hypothalamus via the hypophysial portal vessels (1). [...]
The purpose of this thesis is to present the results of a study on partial perceptual isolation in mentally disturbed individuals which has yielded some new information about the problem of depersonalization and body-scheme. The nature of the methodology, and the material used, seems to warrant some clarification of the motives for this study. The impetus for the investigation came from three different lines of inquiry: (a) - The problem of disorganization of the individual in psychotherapy which, under certain conditions, may yield beneficial results.
Curtis, George. C.
Over the centuries physicians have noted the intimacy of the relationship between "mind" and "body". One of the many quotable statements on the subject was made in 1779 by Dr. William Buchan of Edinburgh, who wrote, "The passions have great influence both in the crate and cure of diseases. How winds act upon matter will, in all probability, ever remain a secret. lt is sufficient for us to know that there is established a reciprocal influence betwixt the mental and corporeal parts and that whatsoever disorders the one, likewise affects the ether." (7) There have been many fruitless debates over the question of whether mind or matter is primary.
"In the name of modernity, for the sake of the nation" : madness psychiatry and politics from the Ottoman Empire to the Turkish Republic (1500s - 1950s) /Ayhan, Caglayan. January 2005 (has links)
Thesis (M.A.)--York University, 2005. Graduate Programme in Social Anthropology. / Typescript. Includes bibliographical references (leaves 296-317). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR26399
Development of radioligands for emission tomography imaging of dopamine D1 and benzodiazepine receptors /Foged, Christian, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 9 uppsatser.
The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg HospitalMungly, Shazia 12 February 2020 (has links)
Background: Various studies have shown that people with serious mental illness have an increased risk for metabolic syndrome with prevalence ranging from 28.7% to 60%. Given the amount of evidence suggesting a link between clozapine and metabolic syndrome, several guidelines have recommended regular clinical monitoring of metabolic syndrome in patients on clozapine. Aim: To determine the screening, prevalence and associated risk factors of metabolic disorders in forensic patients with schizophrenia spectrum disorders who are on clozapine (study group) compared to patients on haloperidol (control group). Methods: It is a retrospective, folder review of forensic male adult patients at Valkenberg Hospital, Observatory Cape Town. Results: There were 45 patients in the study group and 23 patients in the control group. Eight patients (17.8%) in the study group (Clozapine) met criteria for metabolic syndrome according to the NCEP-ATP III criteria and none of the patients in the control group (Haloperidol) did (χ 2 (1) = 4.441, p = .035 V = .257). Patients who had a diagnosis of schizoaffective disorder were also on mood stabilisers in addition to clozapine. Again, while none of the patients on Haloperidol met the criteria for Metabolic syndrome, 6 (24%) of the 25 patients on concurrent Clozapine and sodium valproate did, (χ 2 (1) = 6.051, p = .023 V = .359). In terms of metabolic disorders, a significantly higher proportion of patients in the study group has hypertension and hyperlipidaemia (p = .003 and p = .021 respectively). Less than 25% of all patients were fully screened for metabolic syndrome. There was a very low rate of screening of blood tests: fasting glucose, total cholesterol, trigylcerides, High Density Lipoprotein(HDL) or Low-Density Lipoprotein (LDL). Conclusion: The prevalence of metabolic syndrome was higher in the clozapine group than haloperidol group, which is unsurprising since clozapine is usually associated with a higher risk of metabolic syndrome. However, the prevalence on metabolic syndrome in this study sample was relatively low compared to other studies. This could be due to the low rate of screening of each criteria of metabolic syndrome. Screening for metabolic syndrome should be regularly performed by health professionals in patients with serious mental illness. Further studies are needed to investigate the risk of metabolic syndrome for patients who are on a combination of clozapine and mood stabilisers.
Includes abstract. / Includes bibliographical references. / The co-occurrence of problematic substance use and non-substance use psychopathology is very common in psychiatry, and is generally referred to as comorbidity. The phenomenon has been the subject of debate and widespread research, yet remains poorly understood. The thesis aimed to examine the association between psychopathology and substance use in young people in South African settings, to determine the nature and prevalence of comorbidity, and to identify sociodemographic factors that might influence the associations, as well as the influence of comorbidity on substance use treatment outcomes.
Heroin detoxification during pregnancy: a systematic review and retrospective study of management of heroin addiction in pregnancyGilfillan, Katherine Verne January 2012 (has links)
Includes bibliographical references. / There is a general consensus that methadone maintenance is the gold standard in the management of pregnant heroin users. However, in South African state hospitals, methadone withdrawal is the routine procedure offered to these patients, as methadone maintenance programmes are unavailable in the public sector.
The lived experience of persons with chronic fatigue syndrome : a qualitative phenomenological studyMayers, Patricia Margaret January 2000 (has links)
Bibliography : leaves 99-111. / This phenomenological study examined the lived experience of persons who suffer from Chronic Fatigue Syndrome (CFS). Research into this condition has to date concentrated on causality and coping strategies and there is limited knowledge of the experiences of sufferers of this condition. In-depth interviews were conducted with five participants who met the criteria for the diagnosis of CFS. The interviews were tape-recorded, transcribed verbatim and analysed, coding for thematic content.
Child and adolescent mental health services in the Western Cape of South Africa: policy evaluation, situational analysis, stakeholder perspectives, and implications for health policy implementationMokitimi, Stella 10 September 2021 (has links)
In spite of the need for child and adolescent mental health (CAMH) services across the globe, very little has been done to develop and strengthen CAMH in low- and middle-income countries (LMIC). South Africa is an example of an LMIC where CAMH services have been very limited as a result of various potential factors, including the legacy of apartheid, stigma associated with mental health, and lack of priority of CAMH. In this thesis, we set out to generate an evidence-base about CAMH services in one South African province to inform service strengthening across the full healthcare system through policy development and implementation. We proposed that a comprehensive understanding of specific services requires a multilevel exploration of ‘hardware' (structural) and ‘software' (social) elements in the health systems that support these services. We started by reviewing the CAMH policy landscape with an analysis of the current state of policy development and implementation at national and provincial levels in all nine provinces of South Africa. Using the Walt and Gilson policy analysis triangle (1994), we examined the content, context, processes and actors involved in mental health or CAMH-specific policies. We then evaluated the hardware and software elements of CAMHS in the Western Cape Province by performing a situational analysis using the WHO-AIMS version 2.2 of 2005 (Brief version) adapted for the South African context and to CAMHS. We proceeded to seek the perspectives of stakeholders within the province – firstly a SWOT analysis with senior stakeholders, and secondly, qualitative analysis of the perspectives of grassroots service providers, and of parents/caregivers and adolescent service users. We collected information from these stakeholder groups through a stakeholder engagement workshop, focus group discussions and semi-structured individual interviews. Using the World Health Organization (WHO) (2007) and Gilson (2012) health systems frameworks, we reviewed both the hardware and the software elements of CAMH services and concluded with a synthesis of findings to provide a set of recommendations for policy development and service strengthening based on the evidence generated. In terms of service delivery, findings showed that child and adolescent mental health services (CAMHS) in the Western Cape were provided at all levels of care (primary, secondary and tertiary) and, at least at inpatient and outpatient level, based on catchment/geographical service areas. However, CAMHS were still limited and were provided under very resource-constrained conditions by inadequately trained service providers. In terms of the health workforce, CAMHS were provided by a range of professionals including child & adolescent psychiatrists, general psychiatrists, medical officers, clinical psychologists, social workers, mental health nurses, occupational therapists, and speech and language therapists. However, multidisciplinary expertise and psychosocial interventions were only available in specialist CAMHS at tertiary level of care. In addition, the specialist services were all based in the City of Cape Town, with no direct access to specialist CAMHS at secondary levels of care or in any of the rural districts of the province. Health information systems were not fit-for-purposes to generate disaggregated data on under-18-yearolds, thus made it extremely difficult to provide a comprehensive view of CAMHS in the province. In terms of access to essential medicines, basic classes of psychiatric medications were available at all levels of care, but not consistently so. An exploration of financing showed that no ring-fenced or disaggregated budgets were available for CAMHS, thus making it impossible to comment on the appropriateness of funding for the mental health needs of children and adolescents. In terms of leadership and governance, a national CAMH policy existed, but no implementation plans had been developed since the publication of the CAMH policy in 2003. Our findings highlighted a lack of dedicated CAMH leadership and governance in the province. We argued that the absence of a clear CAMH leadership structure also explained why provincial plans and strategies had not been developed and implemented over the last two decades. A very consistent finding from our data was a need for a dedicated provincial lead for CAMH. We concluded the thesis with hardware and software recommendations for policy implementation, service development, training and research.
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