The purpose of this study was to investigate the behavioral impact of knowledge regarding the relationship between breast cancer, vitamin D supplementation, and sunlight exposure considering levels of self-efficacy and response-efficacy. The study was based on protection motivation theory, which attributes behavior change to cognitive processes related to perceived threats and has demonstrated efficacy in promoting breast cancer risk-reducing behaviors. The study employed a quasi-experimental research design based on a survey using SurveyMonkey. Participants were New York City-residing women ranging in age from 25 to 74 who were recruited via an invitation from SurveyMonkey. Correlation analysis and linear regression analysis were performed on the data extracted from the survey in order to better understand the relationship of the variables in this study, and to test if any of the independent variables were significant predictors of vitamin D intake through supplementation and sunlight exposure. The results of this analysis showed that knowledge regarding the reduction in risk of breast cancer from sunlight exposure and through vitamin D supplementation was not related to changes in behavior involving increases in sunlight exposure and vitamin D intake through supplementation. Further, the results showed that those participants with higher levels of self-efficacy and response-efficacy regarding sunlight exposure and vitamin D supplementation had an increased amounts of vitamin D intake through supplementation on a daily basis. The results of this study can be used to help medical professionals understand the complexity involved in how their clients may or may not take action to reduce the potential for reducing the risk of breast cancer.

The use of human immunodeficiency virus (HIV) counselling and testing (HCT) is a necessary component of implementing HIV prevention and control programs in Nigeria. Knowledge, acceptance, and use of HCT remain low in Nigeria, especially among young people ages 15 to 24 years. The purpose of this study was to ascertain how sociodemographic factors (i.e., gender, place of residence, level of education, geopolitical zone, and socioeconomic status [SES]); cognitive factors (i.e., HCT awareness, knowledge of HIV prevention, and knowledge of HIV transmission); and knowledge of sexual risk behaviors affected HCT uptake among young people in Nigeria using data from the 2013 National HIV/AIDS and Reproductive Health Survey Plus. The study was guided by the social cognitive theory. The sample was composed of 10,091 young people ages 15 to 24 years from all geopolitical zones, SES, and educational backgrounds in Nigeria. Multiple regressions and multivariate comparisons revealed a significant relationship between HCT awareness and HCT uptake (p < .001) and between knowledge of HIV prevention and HCT uptake (p < .001). Sociodemographic variables of gender, place of residence, level of education, geopolitical zone, and SES were also significantly associated with HCT uptake. The sexual risk behavior variables tested were not significantly associated with HCT uptake among young people in Nigeria. The implications for positive social change include providing public health professionals with data to plan and implement HCT awareness and knowledge programs for young people in Nigeria that could increase HCT uptake and reduce the incidence of HIV/AIDS.

Background Motor Vehicle Crashes (MVCs) are a major cause of morbidity and mortality worldwide. This thesis explores the potential use of large databases of primary care medical records to investigate the epidemiology of MVCs in the United Kingdom and to supplement the data available from national statistics, which are believed to understate both the number of crashes, and the number of injuries which occur as a result. Methods Details of all individuals enrolled in The Health Improvement Network (THIN) database whose primary care records indicated involvement in a MVC were used to calculate a series of summary measures describing the burden and consequences of MVCs. These were compared with data available from police accident reports and from hospital admissions. Data from THIN were used to conduct a series of studies of the impact of health and healthcare-related factors on the risk of involvement in MVCs. Specifically: a case-control study of the impact of modifiable lifestyle factors on the risk of MVC; case-crossover and self-controlled case-series studies of the effect of exposure to prescribed medications on the risk of MVC; a case-control study investigating the impact of disordered sleep on the risk of MVC; a case-control study of the risk of involvement in MVC among individuals with diabetes relative to the general population; and; a cohort study assessing whether there is evidence to suggest that involvement in a MVC may indicate the presence of undiagnosed disease which may impair driving performance. Results The socio-demographic characteristics of individuals involved in MVCs recorded in THIN differ markedly from those recorded in police accident reports and hospital admissions data. There was no evidence of consistent trends in MVC incidence over time in the three data sources. Differences in data collection methodology and the severity and scope of crashes recorded may account for these variations. Evidence was found of an association between having a high Body Mass Index and involvement in MVCs, and between past (but not current) smoking and involvement in MVCs, however the recording of data on lifestyle-related exposures such as smoking and alcohol consumption in the age-groups most likely to be involved in MVCs was poor, complicating interpretation of these results. Current exposure to benzodiazepines and preparations containing opioid analgesics was found to increase the risk of involvement in MVCs, as was longer-term use of non-benzodiazepine hypnotics, selective serotonin reuptake inhibitors and antihistamines. No increased risk of MVC was observed with exposure to beta-blockers or tricyclic antidepressants. Individuals reporting insomnia or snoring to their primary care practitioner were found to be at increased risk of MVC, as were individuals with diagnosed sleep apnoea. This association was independent the use of sedative or antidepressant medications. Individuals with diabetes were not found to be at an increased risk of MVC compared with the general population, and there was no difference in risk between those receiving different forms of treatment. Involvement in a MVC was associated with an increased risk of being diagnosed with cardiac disease in the two years following the crash. Conclusions Current sources of data about MVCs in the UK use different data collection methodologies, none of which is likely to accurately describe the overall burden of MVCs in the population. Primary care data remain a useful resource for those wishing to study the epidemiology of MVCs, but care must be taken to ensure that the uses to which the data are put are appropriate. Studies investigating lifestyle-related exposures are unlikely to produce reliable results as primary care recording of such factors is poor in the age-groups most likely to be involved in MVCs. Primary care data are more useful when studying the time course of pharmacological effects, or the effects of diagnosed illness, and can successfully detect previously observed associations. Primary care data is currently of little use in the study of injuries associated with involvement in MVCs as it is rare for both an injury and its proximate cause to be recorded. The investigation of methods by which this problem might be resolved is an important avenue for future research.

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Background: Safety in the housing environment is a basic human need and may be a prerequisite for health but studies from the perspective of the residents are limited in the literature. Although historically public health research has recognized the housing environment as an important determinant of health, there is a need for more research on how housing conditions influence residential well-being. Aim: The overall aim of this thesis was to examine factors and conditions associated with residential well-being and perceived safety in different types of housing areas and to compare safety promotion intervention designs based on residents self-expressed safety needs with corresponding designs developed by local government professionals. Materials and methods: A postal survey (response rate 56%, n=2476) and 11 focus groups (57 participants) were conducted among the residents in 3 small-scale housing areas with detached houses and 3 housing areas with blocks of flats in a Swedish municipality. The areas were geographically contiguous as each of the small-scale areas bordered on an area with blocks of flats. The study municipality is a designated member of WHO Safe Community network that have signed up to work in line with the indicators developed by WHO Collaborating Centre on Community Safety Promotion. Narrative data from a postal questionnaire were used to analyze the lay perspective and identify features perceived to be necessary to feel safe by residents in areas with blocks of flats and small-scale housing areas. Quantitative data were used to examine correlates of local safety-related concerns through a factor analysis. Logistic regression analysis examined associations between high-level scores of the safetyrelated dimensions found and area-level crime rate and being a victim of crime, area reputation, gender, age, education, country of birth, household civil status and type of housing. To examine how self-assessed area reputation is associated with social trust and residential well-being, a multilevel logistic regression analysis was performed using quantitative data, controlling for the random effect of neighbourhood- and individual-level socio-demographic factors. Data from focus group interviews were analyzed to identify mechanisms of how neighbourhood reputation was established. The quality function deployment (QFD) technique was used in a case study to integrate residents’ demands into the design of safety promotion interventions in housing areas. The resulting design was then compared with the safety intervention programme designed by professionals at the municipality administrative office. The results from this comparison were then investigated to identify improvements for the indicators for Safe Homes in the Safe Community programme. Results: The residents’ narratives showed that a stable social structure in the housing area was perceived to be the central factor in a safety-supportive residential environment. Whereas maintenance of good and reassuring relations was emphasized in small-scale housing areas, support for management of poor or even fear-provoking neighbour relations was requested from areas with blocks of flats. The crime rates were lower and safety-related concerns were less in small-scale housing areas. Three composite dimensions (CD) of perceived residential safety were identified: structural indicators of social disorder (CD 1); contact with disorderly behaviour (CD 2); and existential insecurity (CD 3). Area-level crime rates and individual-level variables were associated with dimensions (CD 1) and (CD 3), but only individuallevel variables were associated with dimension (CD 2). The level of residential well-being and social trust was higher in small-scale areas. The housing area reputation was found to be strongly associated with safety-related concerns, residential well-being and social trust. The area reputation also seemed to be a determinant of position in the local social structure; residents were found to position themselves in a rank order. The QFD analysis showed that the initiation and maintenance of social integrative processes in housing areas were the most highly prioritized interventions among the residents, but the analysis did not highlight the safety needs of several vulnerable groups. The Safe Community programme designed by professionals did not address the social integrative processes, but did cover the vulnerable groups. Conclusions: Area reputation is an important and probably underestimated dimension in the development of residential well-being and perceived safety. The QFD technique can be added to the methodological toolbox for residential safety promotion. The technique is particular suitable for providing a quality orientation from the lay perspective on safety promotion in local residential areas. The current Safe Homes concept in the Safe Community programme would benefit from being widened to Safe Housing.

This thesis draws upon data gathered during research undertaken with a grant from the Resuscitation Council (UK). It explores the use of Automatic External Defibrillators (AEDs) by laypeople, which is known as Public Access Defibrillation (PAD). Whilst an abundance of research has been undertaken about this phenomenon, it has predominately been conducted using quantitative methods; however the data I am using was collected using a qualitative approach. During the research, fifty-three semi-structured interviews were carried out. Most of these were with laypeople who had been trained to use AEDs, and nine involved those who delivered the training. These interviews were conducted at sites typical of those where these devices have been introduced, such as railway stations and airports. The geographical area of these locations covered the East and West Midlands, South and West Yorkshire, Lincolnshire and Essex. The aims of the research were quite broad and included exploring how to make training more realistic, how debriefing and support for those who had used an AED should be organised and how the interviewees perceived the technology inherent in the AED. This thesis reanalyses the data that was collected during that research and focuses on two themes. Firstly, some of the theories of technologies in transition are used to illustrate how AEDs were developed in a laboratory and progressed from that setting to become commonplace in public locations. The actor-network theory is adopted to argue that these technological devices exert an influence on the human actors in the networks that exist within society. Specifically, my analysis is informed by the work of Timmermans (1998; 1999; 1997) whose theories about external chest compressions I have developed and applied to AEDs. They suggest that these devices achieved universality, in part, through the influence of debates and medical protocols. One significant factor was that AEDs allowed for defibrillation to be redefined from a medical, to a first aid procedure. Eventually, using these devices was included in the protocols for first aid and this legitimised their use by laypeople. These theories are observable in the data through the interviewees’ accounts of how they came to accept being trained to use AEDs. The experiences of those who had used an AED during a resuscitation attempt are provided and suggest that these are distressing and unpleasant events. Consequently, a key component of this thesis is a discussion of the necessity to provide psychological debriefing for those who have been involved in these incidents. The findings of this thesis suggest that laypeople who have used an AED usually have questions about the actions they took during the attempted resuscitation and need to address these with someone soon afterwards. Generally, they prefer to discuss these issues with a person who has experience of resuscitation and using a defibrillator. However, the provision of such support is often not well organised and individuals are sometimes not aware of what is available to them. I conclude by suggesting that it is important that those who are asked to use an AED have a clearly identifiable person to contact should they need to discuss any issues which may arise. I argue that the responsibility for ensuring that such mechanisms are in place lies with those who instigate the schemes which place AEDs in these locations. Public access defibrillation is a relatively new concept in the UK and I believe that this thesis makes an important contribution to the body of knowledge relating to this phenomenon.

This research explores the understanding of psychosocial risks and work-related stress by international multi-disciplinary experts in developing countries. It further explores their views on the perceived health impact of these issues. It identifies preliminary priorities for action while considering similarities and differences in conceptualizing these issues in industrialized and developing countries. Finally, it explores in what ways these issues can enter the policy agenda in developing countries. This research applies a triangular methodological approach where each stage provides the basis for the development of the next. It starts out with 29 semi-structured interviews to explore the views of experts and also to inform two rounds of an online Delphi survey, which then informed four focus group discussions. The total sample amounted to 120 participants (each sampled once). Key findings for developing countries indicate that a) psychosocial hazards need addressing due to an impact on workers' health; b) occupational health and safety priorities have changed during the last decade pointing to the need for monitoring of psychosocial hazards and the need to address work-related stress, violence, harassment and unhealthy behaviours together with other workplace hazards; c) socio-economic conditions and processes of globalization need attention in the study of psychosocial hazards and an extended research paradigm is required; and d) there is an ever present need for capacity building, stakeholder mobilization, infrastructure development and international exchange and collaboration to address all workplace hazards. Developing countries are not spared from the health and economic impact of psychosocial risks and work-related stress, and there will be a need to address these issues through policy development. To pave the way, this dissertation outlines a need for concerted action at different levels.

Introduction Regular cycling has been shown to improve health and well-being and has a role in tackling obesity and inactivity. Cycle collisions, particularly those involving motorised vehicles, can lead to significant mortality and morbidity and are currently a barrier to wider uptake of cycling. There is evidence that the conspicuity of cyclists may be a factor in some injury collisions. Low-cost, easy to use retro-reflective and fluorescent clothing and accessories (’conspicuity aids’) are widely available. Their effectiveness in reducing the risk of cycling collisions is currently unknown. This study was designed to investigate the relationship between the use of conspicuity aids and risk of collision or evasion crashes for utility and commuter cyclists in an urban setting in the UK. Methods A matched case-control study was undertaken. Cases were adult commuter and utility cyclists who were involved in a crash resulting from a collision or attempted evasion of a collision with another road user. Cases were recruited at a large UK emergency department. Controls were commuter and utility cyclists matched by time and day of travel, season and geographical area of cycling. Controls were recruited at public and private cycle parking sites. Data on the use of conspicuity aids, crash circumstances, participant demographics, cycling experience, safety equipment use and journey characteristics including an estimate of the bicycle crash risk for each chosen route (the number of previous crashes per 100 million kilometres travelled by bicycle calculated for each participant route) were collected using self-completed questionnaires and maps. Conditional logistic regression was used to calculate crude and adjusted odds ratios and 95% confidence intervals of the risk of a crash involving a collision or evasion of a collision with another road user when cyclists reported they were using any item of fluorescent or retro-reflective clothing or equipment vs. none. Unconditional logistic regression was used to analyse associations between participant characteristics and conspicuity aid use. Continuous variables were dichotomised where there was a non-linear relationship to the bicycle crash outcome variable or the primary exposure variable. The sensitivity of the study models to selection, recall and information biases and the effect of missing data was assessed using independent records of conspicuity aid use by potential participants during recruitment. Observations of conspicuity aid use within the study source population at sites across the study catchment area were also conducted by the researcher during the recruitment phase. Results There were 76 cases and 272 controls cyclists who were eligible for inclusion in the primary analysis (response rate of 13% and 54% respectively). The proportion of cases who reported using any item of fluorescent or reflective materials on their clothing or equipment (excluding bicycle mounted reflectors) was higher than for matched controls (cases users 69.7%; 95% CI 58.1% to 79.8% vs. control users 65.4%; 95% CI 59.5% to 79.1%). The unadjusted odds ratio for a collision or evasion crash when using conspicuity aids, was 1.2 (95% CI 0.66 to 2.17). Two alternative modelling strategies were employed. After adjustment for confounding from age, gender, socio-economic deprivation, number of years of cycling experience, bicycle crash risk along each route and cycle helmet use the odds ratio was 1.77 (95% CI 0.74 to 4.25). After adjustment for confounding from age, gender, socio-economic deprivation, bicycle crash risk along each route and history of previous cycle crash involvement the odds ratio was 2.4 (95% CI 1.06 to 5.7). The odds ratio was not significantly affected by adjustment for possession of a driving licence, reported bicycle safety training in childhood, psychometric associates of risk taking behaviour, cycle helmet wearing, years of experience of cycling, distance or number of trips cycled in the previous seven days, type of bicycle, the use of bike-mounted lights or reflectors, weather or lighting conditions, familiarity with the route or alcohol consumption within 8 hours prior to the recorded journey. There was a significant difference between the measure of bicycle crash risk along each route for cases and controls with controls reporting travelling on routes with lower objective bicycle crash risk (median (IQR); cases 378.5 (232.4 to 548.3) vs. controls 268.5 (192.6 to 464.5); p= 0.006). There were no significant differences in route risk for users vs. non-users of conspicuity aids (route risk median (IQR) for conspicuity aid users vs. non-users; 308.1 (198.0 to 504.3) vs. 272.3 (203.7 to 413.4; p= 0.22). Conspicuity aid use was associated with increased length of participant route (unadjusted OR 3.25 for reported route greater than median; 95% CI 2.04 to 5.17 p<0.001), higher numbers of police-recorded bicycle crashes (unadjusted OR 2.26 for greater than median; 95% CI 1.43 to 3.55; p<0.001) and lower numbers of observed cyclists on each route (unadjusted OR 0.999; 95% CI 0.998 to 1.000 p=0.015). Route risk data were missing for 50 participants (15 cases and 35 controls). Validation of the primary exposure showed that there was moderate agreement between participants’ self-reports and independently collected data (kappa 0.42; 95% CI 0.32 to 0.51) but independent data were collected on only 4 eligible cases. Self-reported use of conspicuity aids was higher amongst cases and controls in this study than that observed for cyclists in the study area during the recruitment period (23%; 95% CI 22% to 24%). Discussion The results of this study show a non-significant increase in the odds of a crash for users compared to non-users of conspicuity aids whilst cycling. This association was increased after adjustment for confounders but most models generated to adjust for confounding remained insignificant. No reduction in crash risk could be demonstrated. This is not consistent with the large body of evidence suggesting that conspicuity aids increase the distances from which wearers can be detected and recognised by drivers in a variety of settings. There was evidence that cases were cycling along routes with greater exposure to traffic danger than controls although there were many participants with missing data for this variable potentially introducing a further source of bias. The route risk estimates did not vary significantly between conspicuity aid users and non-users. Residual confounding may have occurred if conspicuity aid users were taking more risks when encountering similar traffic conditions to non-users. This could not be measured but may go some way to explaining these results. If cyclists over-estimate the likely effect of their conspicuity aid use this could result in over compensation and a net increase in crash risk. Adjustment for route risk may have introduced bias by the loss of some participants from the analysis or by acting as a positive suppressor variable increasing the influence of uncontrolled confounding if conspicuity aid use were leading to risky riding over and above the objective risk arising from differing road and traffic conditions. The association between the odds of crash and travelling on roads with higher incidences of previous cycle crashes and fewer cyclists provides support for the “safety in numbers” effect reported in other studies. Differential selection and misclassification biases may also have resulted in over representation of conspicuity aid users amongst cases compared to controls. Social expectation from involvement in a collision crash may have resulted in cases who were not using conspicuity aids being less likely to participate than controls who were non-users. For similar reasons cases may have been more inclined to over-estimate their conspicuity aid use than controls.