Thesis. / Includes reprints of 4 supporting articles. Includes bibliographical references (p. 29-37).

Thesis. / Includes reprints of 4 supporting articles. Includes bibliographical references (p. 29-37).

Thesis (M.S.)--University of Michigan, 1998. / Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1948.

Thesis (doctoral)--München, 1934.

Thesis (doctoral)--München, 1934.

Thesis (M.S.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains x, 43 p. Vita. Includes abstract. Includes bibliographical references (p. 25-26).

Indiana University-Purdue University Indianapolis (IUPUI) / This study was undertaken to investigate histologically the effect of a combination of an antibiotic and an anti-inflammatory enzyme when used as a medication in direct pulp therapy. The pulps of 56 teeth in two Macaca Speciosa monkeys, exposed and left open to the oral environment for 24 hours to insure contamination, received direct treatment with one of four experimental medications: (1) vancomycin, starch, and hyaluronidase; (2) vancomycin, starch, and water; (3) starch and water; and (4) starch and hyaluronidase. At 30 days the teeth were removed from one animal and at 90 days•from the other for histologic interpretation. A satisfactory response was observed in 92.9 per cent of the teeth treated with vancomycin, starch, and hyaluronidase; in 71.5 per cent of the teeth treated with vancomycin, starch, and water; and in 42.9 per cent of the teeth treated with both starch and water and starch and hyaluronidase. None of the teeth treated with vancomycin, starch, and water and vancomycin, starch, and hyaluronidase became necrotic,while 35.7 per cent of the teeth treated with starch and water or starch and hyaluronidase became necrotic. Under the conditions of this investigation, vancomycin containing pulp capping agents are effective in controlling infection and in promoting reparative dentin formation in monkeys. The benefit of hyaluronidase when used in combination with vancomycin was questionable.

Indiana University-Purdue University Indianapolis (IUPUI) / A study was made to develop a method for investigating the quantity and location of vascular leakage during acute inflammation of the dental pulp. Use was made of the method of "vascular labelling" by which carbon particles placed in the blood are deposited in the walls of leaking vessels. Three dogs were used, with cavities of varying depth being cut in their permanent teeth. Vascular leakage was induced in the skin and in some of the teeth by applying histamine phosphate solution. The tissues were studied in normal histologic sections and as cleared specimens. It was found that the number of leaking vessels was much less in the dental pulp than in the skin and that leakage was confined to the area immediately below the cavity preparation unless histamine had been applied to the cavity, when the labelled vessels were found further apically. The number of leaking vessels depended on the depth of the cavity, becoming greater as the cavity depth increased. These findings would support the common finding that the degree of inflammation beneath cavity preparations increases with cavity depth. The conclusion was that the method developed held promise as a tool in investigating vascular changes in the dental pulp.

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