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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Time-delayed models of genetic regulatory networks

Parmar, Kiresh January 2017 (has links)
In this thesis I have analysed several mathematical models, which represent the dynamics of genetic regulatory networks. Methods of bifurcation analysis and direct numerical simulations were employed to study the biological phenomena that can occur due to the presence of time delays, such as stable periodic oscillations induced by Hopf bifurcations. To highlight the biological implications of time-delayed systems, different models of genetic regulatory networks as relevant to the onset and development of cancer were studied in detail, as well as genetic regulatory networks which describe the effects of transcription factors in the immune system. A network of an oscillator coupled with a switch was explored, as systems such as these are prevalent in genetic regulatory networks. The effects of time delays on its oscillatory and bistable behaviour were then investigated, the results of which were compared with available results from the literature.

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