NAND flash-based solid state drives (SSDs) have been widely adopted in data centers and high performance computing (HPC) systems due to their better performance compared with hard disk drives. However, little is known about the reliability characteristics of SSDs in production systems. Existing works that study the statistical distributions of SSD failures in the field lack insights into distinct characteristics of SSDs. In this dissertation, I explore the SSD-specific SMART (Self-Monitoring, Analysis, and Reporting Technology) attributes and conduct in-depth analysis of SSD reliability in a production environment with a focus on the unique error types and health dynamics. QLC SSD delivers better performance in a cost-effective way. I study QLC SSDs in terms of their architecture and performance. In addition, I apply thermal stress tests to QLC SSDs and quantify their performance degradation processes. Various types of big data and machine learning workloads have been executed on SSDs under varying temperatures. The SSD throughput and application performance are analyzed and characterized.