Made available in DSpace on 2014-10-09T12:36:40Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T13:59:09Z (GMT). No. of bitstreams: 1 04230.pdf: 1353263 bytes, checksum: ba0b1a87d30ef196c0398dd1d7b4ca6c (MD5) / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

Made available in DSpace on 2014-10-09T12:27:37Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:04:29Z (GMT). No. of bitstreams: 0 / Cloreto estanoso (SnCl2.2H2O) é o composto mais utilizado na redução do íon pertecnetato (TcO4-), obtido pela eluição do gerador, para a marcação de reagentes liofilizados para radiodiagnóstico. Estes reagentes liofilizados contêm um ligante, cloreto estanoso, e diferentes excipientes. Muitos métodos analíticos para a determinação de estanho não conseguem distinguir entre os íons estanoso (Sn(II)) e estânico (Sn(IV)) em soluções. Os dois métodos, descritos na literatura, para determinação seletiva de Sn(II) são análise titrimétrica e polarografia. O método mais confiável descrito para a quantificação do íon estanoso é a polarografia (voltametria) e pode ser utilizado para a determinação em concentrações de mg e g de Sn(II) e Sn(IV) (0,06-1,0 mg), com boa seletividade. Foi realizada análise titrimétrica, para quantificação de Sn(II), na matéria-prima e em 3 lotes consecutivos de 9 reagentes liofilizados produzidos pelo IPEN-CNEN/SP, utilizando-se sulfato cérico 0,1 mol L-1, diluído 10 vezes e iodo 0,05 mol L-1, diluído 10 vezes, como soluções titulantes. Polarografia por pulso diferencial foi utilizada com configuração convencional composta por três eletrodos: eletrodo de trabalho de gota de mercúrio, eletrodo referência de Ag/AgCl (saturado com KCl) e eletrodo auxiliar de platina. O intervalo de potencial analisado foi de -250 a -800 mV e o pico atribuído à redução de Sn(II) foi encontrado em -370 mV em eletrólito suporte de H2SO4 3 mol L-1 e, para Sn(IV), -470 mV, em eletrólito suporte de HCl 3 mol L-1. Para retirada do oxigênio da solução na cela polarográfica utilizou-se nitrogênio 5.0 por 5 minutos, antes e após cada introdução de amostra. Para determinação de Sn(IV) foi feita a oxidação do Sn(II), por adição de peróxido de hidrogênio, em 37 ± 5 ºC, por 5 minutos, seguida de purga com nitrogênio, e análise. A análise polarográfica desenvolvida mostrou-se adequada para a determinação de Sn(II), na presença de Sn(IV), e de estanho total nos kits radiofarmacêuticos estudados. / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / A equivalÃncia farmacÃutica entre dois medicamentos relaciona-se à comprovaÃÃo de que ambos contÃm o mesmo fÃrmaco (mesma base, sal ou Ãster da mesma molÃcula terapeuticamente ativa), na mesma dosagem e forma farmacÃutica, o que pode ser avaliado por meio de testes in vitro. No Brasil, os medicamentos alopÃticos sÃo divididos em trÃs categorias quanto ao registro junto à AgÃncia Nacional de VigilÃncia SanitÃria: medicamentos novos, medicamentos similares e medicamentos genÃricos. O objetivo foi avaliar a EquivalÃncia FarmacÃutica da Carbamazepina 200 mg (CBZ) e Diazepam 10 mg (DZP) comercializados no programa FarmÃcia Popular do Brasil, visando discutir a importÃncia da qualidade dos medicamentos para a saÃde pÃblica. Utilizou-se como SubstÃncia QuÃmica de ReferÃncia (SQR) carbamazepina e diazepam, com teor declarado de 99,6 e 99,9%, respectivamente. Realizaram-se testes fÃsico-quÃmicos tais como: determinaÃÃo de peso mÃdio, desintegraÃÃo, dureza, friabilidade, teor, uniformidade de conteÃdo e perfil de dissoluÃÃo, segundo a FarmacopÃia Brasileira (F.Bras.) 4a ediÃÃo. Os resultados indicaram uma dureza menor nos comprimidos de DZP da FarmÃcia Popular. Em relaÃÃo ao Perfil de dissoluÃÃo da CBZ, a anÃlise por ANOVA indicou haver diferenÃas significativas (p<0,05) entre os perfis de dissoluÃÃo da FarmÃcia popular em relaÃÃo ao genÃrico e referÃncia nos tempos avaliados. Comparou-se o perfil de dissoluÃÃo do comprimido da FarmÃcia Popular em relaÃÃo ao medicamento referÃncia, atravÃs dos cÃlculos dos fatores de diferenÃa (f1) e semelhanÃa (f2). Obteve-se um valor de 46,29 e 35,00, respectivamente, indicando diferenÃas nos perfis avaliados. Nos comprimidos de DZP, verificou-se que os valores de percentagem de fÃrmaco dissolvido para as trÃs amostras avaliadas, foram superiores a 85% em 15 minutos de teste, e a comparaÃÃo pelo cÃlculo dos fatores de f1 e f2, nÃo pÃde ser aplicada neste caso. Evidenciou diferenÃa (p<0,05) nos primeiros 75 minutos avaliados para as trÃs amostras, o que pode nÃo ter uma significÃncia farmacÃutica. Os outros parÃmetros fÃsico-quÃmicos cumpriram com as especificaÃÃes da F. Bras. em todas as amostras de CBZ e DZP. Portanto, os comprimidos de CBZ da FarmÃcia Popular nÃo sÃo equivalentes farmacÃuticos em relaÃÃo ao medicamento referÃncia. / Two drugs are considered pharmaceutically equivalent when both contain the same drug (base, salt or ester of the same active ingredient), at the same dosage and pharmaceutical form determined in vitro. In Brazil, the allopathic drugs are classified into three cathegories when registered in the Brazilian health surveillance agency (AgÃncia Nacional de VigilÃncia SanitÃria): new, similar or generic drugs. This work aimed to determine the pharmaceutical equivalence of Carbamazepine 200 mg (CBZ) and Diazepam 10 mg (DZP) marketed in the Brazil Popular Pharmacy program, discussing the importance of drugs for public health. Carbamazepine SQR and Diazepam SQR were used as reference drugs with 99.6 and 99.9% declared content, respectively. Physicochemical studies, such as mean weight, disintegration, hardness, friability, content, content uniformity and dissolution profile were performed in accordance to Brazilian Pharmacopeia 4th edition. The results indicated a lower hardness of DZP Popular Pharmacy tablets. Despite the dissolution profile of CBZ, the ANOVA test presented significant statistical difference (p<0.05) between Popular Pharmacy tablets and generic or reference drugs in all the time point evaluated. The dissolution profile of Popular Pharmacy and reference tablets were compared through the f1 (difference) and f2 (similarity) factors. Values of 46.29 and 35.00 respectively were found suggesting a difference on the profiles evaluated. The DZP tablets, despite the sample, showed a dissolution fraction higher than 85% in 15 minutes. f1 and f2 were not possible to be calculated in these cases. The variance analysis evidenced, for all the samples, statistical difference (p< 0.05) in the first 75 minutes evaluated, what might not have pharmaceutical importance. The other physicochemical parameters were in accordance with Brazilian Pharmacopeia for all the CBZ and DZP samples. Therefore, the CBZ tables cannot be considered pharmaceutically equivalents to the reference ones.

M.Ing. / Please refer to full text to view abstract

M. Phil.

This dissertation is based on the assumption that the Port Elizabeth Municipality should deliver essential services effectively, efficiently and economically so as to attain excellence in service delivery. The essential services dealt with in this study are electricity; refuse collection; sewerage; and water services. Attaining excellence in service delivery will lead the Port Elizabeth Municipality to improve and sustain the quality of life of the local inhabitants. The primary objectives of this dissertation include, inter alia: An historical analysis of delivery systems of the former government prior to 1994, which provides the primary reasons and purposes of delivery systems, and the effects on the Port Elizabeth Municipality. Reformation and transformation of South African local government since 1994, with particular reference to the Port Elizabeth Municipality. A normative model for service delivery, which is designed to accelerate service delivery in the local spheres of government, with special reference to the Port Elizabeth Municipality as the locus of this study. The nature, extent and evaluation of the existing service delivery by the Port Elizabeth Municipality from 1994 to 1999. An empirical survey is conducted in the form of questionnaires to the directors, heads of departments, senior managers, as well as councillors. Approaches and strategies for attaining excellence in service delivery, which include, inter alia: a government-business paradigm and an equilibrium approach. Lastly, a number of recommendations are made and conclusions are drawn based on the findings of the empirical survey in order to deliver essential services equitably, efficiently, effectively and economically to attain excellence in service delivery in the Port Elizabeth Municipality.

No description available.

M.Phil. / A project is successful if it is finished on time, to cost and to quality. Time and cost are relatively easy to understand and measure, however it is not easy to measure quality during the project life cycle. In spite of quality being stated as one of the major criteria of project success, appropriate attention to this is not always given in the context of projects. There are several possible definitions of good quality on a project. A project is said to be of good quality if the project's outcome has the following [17]: • Meets the specification • Is fit for purpose • Meets the customer's requirements • Satisfies the customer. Projects based organisations design and build complex items/systems such as aircraft or locomotives in relatively low volumes, or design and construct bridges, processing plants, that are unique, and once-off projects. Products such as aircraft have extended working lives, therefore after-sales support such as maintenance, servicing and upgrading are more important than for product-based organisations. A great proportion of management and engineering effort is therefore absorbed by such support functions. In projects more effort goes into design and production or construction engineering compared with product based organisations. According to Carruthers [3] "Very often projects that have been successfully completed within nominal scope, time and cost from the project manager's point of view turn out to be failures in the long term because of operational, product quality and/or marketing problems. The positive or negative influence of quality lasts long after 'cost successes' or 'schedule compliance' have been discounted or even forgotten." Examples of projects, which failed due to what the author regards as 'poor quality', will be discussed at the end ofthis dissertation (i.e. in chapter five).

M.Ing. / Many small emerging engineering companies, in especially South Africa, employ only a single engineer (this is mainly due to the shortages of qualified engineering staff). The engineers in many small engineering companies find themselves in the situation where they are responsible for many areas and fields, from design, management and in some cases finances too. This leaves very little time to plan projects with the detailed attention that each and every project requires no matter how small or large. It was the famous and true words of Harvey MacKay, “If you fail to plan, you plan to fail”, that if any project is undertaken without planning is going to fail on some level. It is undertaken, in this dissertation, to investigate the classical project management process and to ascertain the possibility of simplifying this process so that engineers in small engineering companies have an effective project management process that is economically feasible and will fit into already tight project time lines. A survey was conducted in order to get a good understanding of how project management is viewed in small engineering companies. The results of the survey support the theory that project management in small engineering companies is sadly lacking, and is viewed as an expense rather than a tool. Two case studies were performed; these highlight the value of project management. Initially poor project management leads to successful although late projects; with an improvement of the project breakdown structure and improved project management skills the second case study had some very surprising results. Finally the conclusion highlights that project management has very positive impacts on even the smallest of projects. Unfortunately there are no shortcuts when it comes to project management and what you put in is what you can expect to get out.

Chapter 1 gives a brief introduction to statistical quality control (SQC) and provides background information regarding the research conducted in this thesis. We begin Chapter 2 with the design of Shewhart-type Phase I S2, S and R control charts for the situation when the mean and the variance are both unknown and are estimated on the basis of m independent rational subgroups each of size n available from a normally distributed process. The derivations recognize that in Phase I (with unknown parameters) the signaling events are dependent and that more than one comparison is made against the same estimated limits simultaneously; this leads to working with the joint distribution of a set of dependent random variables. Using intensive computer simulations, tables are provided with the charting constants for each chart for a given false alarm probability. Second an overview of the literature on Phase I parametric control charts for univariate variables data is given assuming that the form of the underlying continuous distribution is known. The overview presents the current state of the art and what challenges still remain. It is pointed out that, because the Phase I signaling events are dependent and multiple signaling events are to be dealt with simultaneously (in making an in-control or not-in-control decision), the joint distribution of the charting statistics needs to be used and the recommendation is to control the probability of at least one false alarm while setting up the charts. In Chapter 3 we derive and evaluate expressions for the run-length distributions of the Phase II Shewhart-type p-chart and the Phase II Shewhart-type c-chart when the parameters are estimated. We then examine the effect of estimating and on the performance of the p-chart and the c-chart via their run-length distributions and associated characteristics such as the average run-length, the false alarm rate and the probability of a “no-signal”. An exact approach based on the binomial and the Poisson distributions is used to derive expressions for the Phase II run-length distributions and the related Phase II characteristics using expectation by conditioning (see e.g. Chakraborti, (2000)). We first obtain the characteristics of the run-length distributions conditioned on point estimates from Phase I and then find the unconditional characteristics by averaging over the distributions of the point estimators. The in-control and the out-of-control properties of the charts are looked at. The results are used to discuss the appropriateness of the widely followed empirical rules for choosing the size of the Phase I sample used to estimate the unknown parameters; this includes the number of reference samples m and the sample size n. Chapter 4 focuses on distribution-free control charts and considers a new class of nonparametric charts with runs-type signaling rules (i.e. runs of the charting statistics above and below the control limits) for both the scenarios where the percentile of interest of the distribution is known and unknown. In the former situation (or Case K) the charts are based on the sign test statistic and enhance the sign chart proposed by Amin et al. (1995); in the latter scenario (or Case U) the charts are based on the two-sample median test statistic and improve the precedence charts by Chakraborti et al. (2004). A Markov chain approach (see e.g. Fu and Lou, (2003)) is used to derive the run-length distributions, the average run-lengths, the standard deviation of the run-lengths etc. for our runs rule enhanced charts. In some cases, we also draw on the results of the geometric distribution of order k (see e.g. Chapter 2 of Balakrishnan and Koutras, (2002)) to obtain closed form and explicit expressions for the run-length distributions and/or their associated performance characteristics. Tables are provided for implementation of the charts and examples are given to illustrate the application and usefulness of the charts. The in-control and the out-of-control performance of the charts are studied and compared to the existing nonparametric charts using criteria such as the average run-length, the standard deviation of the run-length, the false alarm rate and some percentiles of the run-length, including the median run-length. It is shown that the proposed “runs rules enhanced” sign charts offer more practically desirable in-control average run-lengths and false alarm rates and perform better for some distributions. Chapter 5 wraps up this thesis with a summary of the research carried out and offers concluding remarks concerning unanswered questions and/or future research opportunities. / Thesis (PhD)--University of Pretoria, 2009. / Mathematics and Applied Mathematics / unrestricted