Software Defined Radios (SDRs) and Cognitive Radios (CRs) pave the way for next-generation radio technology. They promise versatility, flexibility and cognition which can revolutionize communications systems. However they present greater challenges to the design of radio frequency (RF) front-ends. RF front-ends for the radios in use today are narrow-band in their frequency response and are optimized and tuned to the carrier frequency of interest. SDRs and CRs demand front-ends which are versatile, configurable, tunable and be capable of transmitting and receiving signals with different bandwidths and modulation schemes. Integrating power amplifiers (PAs) with transmitters in CMOS has many advantages and challenges. This thesis deals with the design of an RF transmitter front-end for SDRs and CRs in CMOS. The thesis begins with an introduction to SDRs and the requirements they place on transmitters and the challenges involved in designing them in CMOS. After a brief overview of the existing techniques, the proposed architecture is presented and explained. A digitally intensive transmitter solution is proposed. The transmitter covers a wide frequency range of 750 MHz to 2.5 GHz. The inputs to the proposed transmitter are in-phase and quadrature (I & Q) data bit streams. Multiple stages of up-sampling and filtering are used to remove all spurs in the spectrum such that only the harmonics of the carrier remain. Differential rail-to-rail quadrature clocks are generated from a continuous wave signal at twice the carrier frequency. The clocks are corrected for their duty cycle and quadrature impairments. The heart of the transmitter is an integrated reconfigurable CMOS power amplifier (PA). A methodology to design reconfigurable Class E PAs with a series fixed inductor has been presented. A CMOS power amplifier that can span a wide frequency range with sufficient output power and efficiency, supporting varying envelope complex modulation signals, with good linearity has been designed. Digital pre-distortion (DPD) is used to linearize the PA. The full transmitter and the clock correction blocks have been designed and fabricated in a commercial 130-nm CMOS process and experimentally characterized. The PA delivers a maximum power of 13 dBm with an efficiency of 27% at 1 GHz. While transmitting a 16-QAM signal at 1 GHz, the measured EVM is 4%. It delivers a maximum power of around 11-13 dBm from 750 MHz to 1.5 GHz and up to 6.5 dBm of power till 2.5 GHz. Comparing the proposed system with recently published literature, it can be seen that the proposed design is one of the very few transmitters which has an integrated matching network, tunable across the frequency range. The proposed PA produces the highest output power and with largest efficiency for systems with on-chip output networks.