Thesis (M.B.A.)--University of Hong Kong, 1992.

Thesis (M.Hous.M.)--University of Hong Kong, 2004. / Also available in print.

Thesis (Ph.D.)--University of North Carolina at Charlotte, 2004. / Includes bibliographical references (leaves 127-136).

Thesis (M. Hous. M.)--University of Hong Kong, 2006.

Thesis (Ph. D.)--Case Western Reserve University, 2006. / [School of Medicine] Department of Epidemiology and Biostatistics. Includes bibliographical references. Available online via OhioLINK's ETD Center.

Purpose of this study was to validate a novel CyberKnife stereotactic body radiotherapy (SBRT) treatment planning on an MRI-based 3D prostate model insert in an anthropomorphic pelvis phantom using Gafchromic EBT3 films to perform dosimetric measurements. The methodology of this study is based on a pelvis phantom and a physical printed 3D model of the prostate with dominant intra-prostatic-lesion and surrounding organs at risk segmented from a patient MR images. Cyberknife prostate treatment planning was performed to have at least 95% the planning target volumes (PTV: prostate expanded with margins of 5 mm in all directions except 3 mm posteriorly) covered by 3625 cGy (725x5) and a simultaneous dose escalation to 4750 cGy on the dominant intra-prostatic-lesion. Plan dosimetry verification was performed using Gafchromic EBT3 films on a Stereotactic Dose Verification Phantom. First, film calibration was done on Gafchromic EBT3 films exposed to various doses of 0-2500 cGy based on a LINAC (Trilogy) and CyberKnife monthly quality assurance (QA) for machine output calibration. Second, absolute dose measurements were taken by using films within the dose range 0-2250 cGy. Third, Gafchromic EBT3 films were placed in coronal and sagittal planes on the standard “blue phantom” or Stereotactic Dose Verification Phantom (SDVP) on which one fraction of the treatment plan is delivered for verification measurements. Then, on the prostate-pelvis phantom, a dosimetry inserts were used with films through the DIL region. After the calibration, the accuracy of absolute dose measurements with EBT3 was verified to be ≤ 1% in the dose range of interest (500-1500 cGy). On the SDVP phantom, comparison of films vs. plan for the coronal plane yielded ≥ 99.7% passing rates while for sagittal plane yielded ≥ 95.3% passing rates under the gamma criteria of ≤ 2% in dose and ≤ 2mm in distance to agreement (DTA). This study demonstrated that it is feasible to plan and deliver a SBRT treatment to prostate with a simultaneous dose escalation to the dominant intra-prostatic lesion.

Orientador: Glaucia Aparecida Prates / Coorientador: Antonio Francisco Savi / Banca: Fernando de Lima Caneppele / banca: Adriano dos Reis Lucente / Resumo: A gestão de riscos tem se apresentado como uma opção muito próspera para empresas de diversos setores, pois desenvolve chances maiores de análise e controle de perdas para a direção da organização empresarial, além de promover maior competitividade junto a suas concorrentes no tocante a melhores práticas de gestão. Devido a uma carência de estudos sobre os riscos nestas operações, observou-se a necessidade de propor uma estrutura conceitual para analisar e avaliar os riscos intrínsecos nas operações Corte, Transbordo e Transporte de Cana de Açúcar (CTT) em uma empresa paulista do setor sucroenergético. Esta pesquisa é de caráter qualitativo e composta por três etapas. A primeira etapa envolveu uma revisão bibliográfica sobre os temas de gestão de riscos, normas internacionais, ferramentas de análise de riscos e setor sucroenergético. Na segunda etapa, foram realizadas técnicas como análise de documentos, observação participante e entrevistas semiestruturadas com oito especialistas, com o intuito de entender mais profundamente os riscos incorridos no Sistema CTT. Na terceira etapa da pesquisa, apresentou-se uma estrutura conceitual para análise e avaliação de riscos no Sistema CTT utilizando como base, as ferramentas extraídas das normas internacionais de gestão de riscos que mais se harmonizaram com a estrutura sugerida de análise e avaliação de riscos, sendo elas Análise de Árvore de Falhas (FTA), Análise da Gravata Borboleta (Bow-Tie) e Matriz de Risco (Probabilidade e Cons... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Risk management has proven to be a very successful option for companies in many sectors, as it develops greater chances of analysis and loss control for the direction of the business organization, as well as promoting greater competitiveness among its competitors regarding best practices in management. Due to a lack of risk studies in these operations, it was observed the need to propose a conceptual framework to analyze and evaluate the intrinsic risks in the operations Cut, Transhipment and Transport of Sugar Cane (CTT) in a São Paulo company of the sugar-energy sector . This research is qualitative and consists of three stages. The first step involved a literature review on the topics of risk management, international standards, risk analysis tools and the sugar and ethanol sector. In the second stage, techniques such as document analysis, participant observation and semi-structured interviews with eight specialists were carried out, in order to understand more deeply the risks incurred in the CTT System. In the third stage of the research, a conceptual framework for risk analysis and evaluation was presented in the CTT System using as a basis the tools extracted from international risk management standards that were most in harmony with the suggested structure of risk analysis and evaluation, such as Fault Tree Analysis (FTA), Bow-Tie Analysis, and Risk Matrix (Probability and Consequence). As a result, it can be concluded that this conceptual framework for risk analysis ... (Complete abstract click electronic access below) / Mestre

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