Yes / This article examines the mediating mechanism of the relationship between institutional voids (IVs) and inter-firm cooperation and the moderating role of economic adversity in the context of small and medium-sized enterprises (SMEs) based in emerging markets. The hypotheses are tested using time-lagged survey data from 214 SMEs from Ghana. The findings provide support for the hypotheses by showing that (1) IVs positively influence the use of government research and development (R&D) support, (2) the use of government R&D support mediates the relationship between IVs and inter-firm cooperation, and (3) economic adversity positively moderates the relationship between IVs and the use of government R&D support. The findings contribute to understanding the role of IVs in inter-firm cooperation. Implications for theory and practice are discussed.