Abstract Image The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DNA alkylators and have antitumor activity independent of the O6-methylguanine-DNA methyltransferase and DNA mismatch repair constraints that limit the use of Temozolomide.

There has been no real attempt to explore the contribution and effectiveness of inspection as a catalyst for change and improving service provision. In England the Government is currently reviewing the way that one regulatory body, the Commission for Social Care Inspection (CSCI), operates and carries out its inspection functions in relation to care homes for older people. This article reports on a study carried out in 2004 that asked managers of care homes for older people about their views and experiences of inspection and ways to improve the process. The findings endorse inspection as a necessary intervention. Managers identified that the main purposes of inspection were: to ensure the well-being of residents; to achieve or comply with standards; to check that the home was running properly and to act as a double check against the homes own audits. The two most useful aspects of inspection were as a means of providing feedback and as support and guidance to managers. The expertise of the inspector needs to be better deployed to drive up standards of care and maximise their influence to promote an improvement in services and innovation in practice.

No description available.

The book provides critical perspectives that reach beyond the technical approaches of international financial institutions and proponents of the liberal peace formula. It investigates political economies characterized by the legacies of disruption to production and exchange, by population displacement, poverty, and by 'criminality'.

The Bode-Fano integral can be used as an objective tool for assessing the bandwidth of antennas, and especially schemes for bandwidth improvement. Results for U-slot and E-slot dual resonant patch antennas suggest that the Fano integral is invariantly related to the overall volume. The Bode-Fano and Youla theories of broadband matching have been applied to the narrowband and wideband lumped equivalent circuit of microstrip antennas to calculate the maximum achievable return loss-bandwidth product of linearly polarized microstrip antennas. Curves are presented showing the relation between the antenna bandwidth, maximum achievable return loss, and parameters of the equivalent circuit. It has been shown that creating parallel slots on the patch despite all potential advantages, may reduce the potential bandwidth of patch antennas.

No / Perceived time is inherently malleable. For example, adaptation to relatively long or short sensory events leads to a repulsive aftereffect such that subsequent events appear to be contracted or expanded (duration adaptation). Perceived visual duration can also be distorted via concurrent presentation of discrepant auditory durations (multisensory integration). The neural loci of both distortions remain unknown. In the current study we use a psychophysical approach to establish their relative positioning within the sensory processing hierarchy. We show that audiovisual integration induces marked distortions of perceived visual duration. We proceed to use these distorted durations as visual adapting stimuli yet find subsequent visual duration aftereffects to be consistent with physical rather than perceived visual duration. Conversely, the concurrent presentation of adapted auditory durations with nonadapted visual durations results in multisensory integration patterns consistent with perceived, rather than physical, auditory duration. These results demonstrate that recent sensory history modifies human duration perception prior to the combination of temporal information across sensory modalities and provides support for adaptation mechanisms mediated by duration selective neurons situated in early areas of the visual and auditory nervous system (Aubie, Sayegh, & Faure, 2012; Duysens, Schaafsma, & Orban, 1996; Leary, Edwards, & Rose, 2008). / Wellcome Trust (WT85315 & WT097387), and The Federation of Ophthalmic and Dispensing Opticians

No / The first issue of Psychology & Marketing was published in 1984. The journal was conceived as a forum for academics and practitioners in psychology, marketing, and related fields to engage in an exchange of scholarly information. The raison d'être of the journal was to bring psychologically sophisticated information and methodologies to bear on all aspects of marketing theory and practice. This review analyzes the performance of Psychology & Marketing from several perspectives, and includes data comparing its performance to the performance of other journals. Looking back over the last 25 years of its history, it seems fair to conclude that Psychology & Marketing has clearly delivered on its tacit promise of effectively building the knowledge base of marketing through psychology-based insights. Looking forward, it seems reasonable to anticipate that the journal's well-established track record in terms of diversity in the content, research design, and methodologies of its published articles will continue to stand as a welcome and refreshing distinction from other journals covering comparable domains of study

No / The past two decades have seen important changes in the ways in which archaeologists perceive interpersonal violence in the past. Prehistoric archaeology in particular provides a unique long-term perspective on the development and institutionalization of violence in human societies, adding a further dimension to the work of cultural anthropologists studying more recent non-state societies. Evidence can be drawn from a range of sources, including material culture, settlement patterning, iconography and (crucially) patterns of trauma in human remains. The interpretation of such evidence remains inseparable from wider contextual understandings of prehistoric social forms and practices. This paper considers the specific role of archaeological evidence in establishing a broader historical context for the study of violence.

No / Greene was Team Leader for this applied research project for the UK (DFID), commissioned on the basis of his extensive recent research on community security and justice issues in numerous fragile states including Ethiopia. He was lead author for the research and the Report. The work is original, rigorous and based on extensive new field work and primary data collection. It had high impact: in 2012 on the basis of this Report the UK (DFID) established a major (over £20 million) community security and justice programme with Ethiopia, designed according to our findings and recommendations.

Biodegradable, biocompatible polylactide (PLA) synthesized from renewable resources has attracted extensive interests over the past decades and holds great potential to replace many petroleum-derived plastics. With no loss of biodegradability and biocompatibility, we highly toughened PLA using a novel bioelastomer (BE)–synthesized from biomass diols and diacids. Although PLA and BE are immiscible, BE particles of ∼1 μm in diameter are uniformly dispersed in the matrix, and this indicates some compatibility between PLA and BE. BE significantly increased the cold crystallization ability of PLA, which was valuable for practical processing and performance. SEM micrographs of fracture surface showed a brittle-to-ductile transition owing to addition of BE. At 11.5 vol%, notched Izod impact strength improved from 2.4 to 10.3 kJ/m2, 330% increment; the increase is superior to previous toughening effect by using petroleum-based tougheners.