Compressed sensing (CS) is an innovative approach of signal processing that facilitates sub-Nyquist processing of bio-signals, such as a neural signal, electrocardiogram (ECG), and electroencephalogram (EEG). This strategy can be used to lower the data rate to realize ultra-low-power performance, As the count of recording channels increases, data volume is increased resulting in impermissible transmitting power. This thesis work presents the implementation of a CMOS-based front-end design with the CS in the standard 180 nm CMOS process. A novel pseudo-random sequence generator is proposed, which consists of two different types of D flip-flops that are used for obtaining a completely random sequence. This thesis work also includes the (reverse electrowetting-on-dielectric) REWOD based energy harvesting model for self-powered bio-sensor which utilizes the electrical energy generated through the process of conversion of mechanical energy to electrical energy. This REWOD based energy harvesting model can be a good alternative to battery usage, particularly for the bio-wearable applications. The comparative analysis of the results generated for voltage, current and capacitance of the rough surface model is compared to that of results of planar surface REWOD.