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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Examining the roles of microRNAs in Aedes aegypti and Drosophila melanogaster spermatogenesis

Safi, Hamza 15 January 2014 (has links)
MicroRNAs (miRNAs) are small, non-coding RNAs that act as regulators of gene expression at the post-transcriptional level in plants and animals. In animal cells, miRNAs typically bind with imperfect complementation to sequences within the 3′ UTRs of mRNAs, thereby inhibiting the translation of the transcripts. MiRNAs affect a variety of developmental pathways, and some of them appear to play important roles in defining the differential gene expression within the mammalian testis and during spermatogenesis; their functions in insects, however, remain largely unexplored. In this study, I examined the expression of several putative testis-specific miRNAs in different tissues and developmental stages of the mosquito Aedes aegypti and the vinegar fly Drosophila melanogaster. MiRNAs -9, -34, -100, -124, and -219 were all expressed in the testes of the two insects, but some differences in their expression in other tissues were observed. One particular miRNA, miR-34, was examined more thoroughly, and was confirmed to target genes that either have functions in spermatogenesis or have a testis-specific expression pattern in the two dipteran insects. Inhibition of miR-34, using antisense oligonucleotides, and RNA interference-mediated knockdown of its target, aae/014067, in A. aegypti negatively impacted the fertility of the mosquito males. These results suggest that both aae/014067 and miR-34 are clearly associated with A. aegypti male fertility and the disruption of their normal expression could render mosquitoes sterile, which would help in the development of sterile male release programs, to reduce the risk of mosquito-borne disease without the use of broad-spectrum pesticides that kill many non-target species.
2

Studies on the binding of E. coli RNA polymerase to E. coli DNA

Ford, Keith Bradley, January 1976 (has links)
Thesis--Wisconsin. / Includes bibliographical references (leaves 74-79).
3

Allosteric regulation of mRNA metabolism : mechanisms of cap-dependent regulation of poly(A)-specific ribonuclease (PARN) /

Nilsson, Per, January 2008 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2008. / Härtill 5 uppsatser.
4

Developing tools for RNA structural allignment

Mokdad, Ali G. January 2006 (has links)
Thesis (Ph.D.)--Bowling Green State University, 2006. / Document formatted into pages; contains xii, 145 p. : ill. (some col.) Includes bibliographical references.
5

Nuclear function and regulation of gene expression in rat liver in vivo and rat hepatoma cells in culture

Bushnell, Donald Eduard, January 1976 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1976. / Typescript. Vita. Includes bibliographical references.
6

Physical studies on the ribosomes and ribosomal ribonucleic acid of Escherichia coli

Stanley, Wendell M. January 1963 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1963. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 172-177).
7

Catalogs and analyses of products of limited hydrolysis of R17 and Q[beta] ribonucleic acids

Samuelson, Gay Marie, January 1969 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Vita. Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
8

Physical, chemical, and crystal structure studies of transfer RNA

Hampel, Arnold Everett, January 1969 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
9

Molecular Insights into Kcnq1ot1 Noncoding Antisense RNA Mediated Long Range Transcriptional Gene Silencing /

Pandey, Radha Raman, January 2008 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2008. / Härtill 4 uppsatser.
10

Lead(II) as a tool for probing RNA structure in vivo /

Lindell, Magnus, January 2005 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2005. / Härtill 5 uppsatser.

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