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mRNA Cap Methylation in Pluripotency and DifferentiationGrasso, L., Suska, O., Davidson, L., Gonatopolous-Pournatzis, T., Williamson, Ritchie, Wasmus, L., Wiedlich, S., Peggie, M., Stavridis, M.P., Cowling, V.H. 02 August 2016 (has links)
Yes / The mRNA cap stabilizes transcripts and
recruits processing and translation
factors. Grasso et al. report that the
mRNA cap methyltransferase RNMTRAM
is highly expressed in embryonic
stem cells and is important for
pluripotency-associated gene
expression. Repression of RAM occurs
during neural differentiation and is
important for expression of neuralassociated
genes. / Wellcome Trust
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