M.Tech. (Radiography) / Conventional film and paper based radiology departments have been replaced by information technology at a rapid rate internationally. The leading technology is the Picture Archiving and Communication Systems (PACS) and Radiology Information System (RIS). The necessity to follow global trends has become more apparent in Africa. Simultaneously, Gauteng has now reached a stage where PACS and RIS have been widely implemented. It has been recommended that radiographers must be prepared for the change in expectations and levels of accountability required when PACS and RIS are adopted into the radiology department. The research question that arises is: What are the experiences of radiographers using PACS and RIS in Gauteng, South Africa? The aim and objectives of this explanatory sequential study was to explore and describe the experiences of radiographers using PACS and RIS in Gauteng, South Africa and to develop guidelines to facilitate the job satisfaction of radiographers in a PACS and RIS-driven radiology department. The study employed an explanatory sequential mixed methods design. The explanatory design is a two-phased mixed methods design. The study began with the first, quantitative phase in which the researcher collected data from the six participating diagnostic radiology practices in the form of questionnaires. For the second phase the researcher interviewed information-rich radiographers who participated in the first phase of the data collection in focus groups. The findings, of this study, indicate that the participants in this study experience PACS and RIS in a positive manner, but that strategies could be put into place to further enhance their experience. Guidelines for facilitating job satisfaction of radiographers in a PACS and RIS-driven radiology department are suggested