Addenda inserted inside back fly-leaf. / Bibliography: leaves 185-229. / xxiv, 229, [42] leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Using a rat model of CRF (chronic renal failure), examines the effects of treatment with recombinant human (rh)IGF-I, rhGH and rhIGH-I + GH. Tests the hypothesis that uraemic resistance to both GH and IGF-I is evident in derangements in the GH/IGF-I axis contribution to growth retardation in children with CRF. / Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 1996?